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Neuroanatomical mechanisms of opioid inhibition and sensitization of mesolimbic and incerto-hypothalamic DA transmission. Opioids such as β-endorphin disinhibit dopamine release during sexual arousal and desire, but inhibit it at orgasm. This inhibition, however, results in sensitization of dopamine in subsequent trials [163,164]. Adapted from Barrot et al. [165] (2012, Barrot et al.)
