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. 2022 Aug 11;23(16):8979. doi: 10.3390/ijms23168979

Table 1.

Characterization of the most common NLRP3 inhibitors used in AD research.

Compound Code of Inhibitor Chemical Name ofInhibitor Chemical Structure of Inhibitor Mechanism of Action Research Models
MCC950
(also known as CRID-3 or CP-456773)		 1-(1,2,3,5,6,7-Hexahydro-s-indacen-4-yl)-3-[4-(1-hydroxy-1-methyl-ethyl)-furan-2-sulfonyl]urea graphic file with name ijms-23-08979-i001.jpg inhibition of NACHT domain of NLRP3
  • -

    APP/PS1 AD mouse model [110]

  • -

    sporadic AD mouse model [111]

  • -

    SAMP8 mouse model [112]
JC124 (5-Chloro-2-methoxy-N-(4-(N-methylsulfamoyl) phenethyl)benzamide graphic file with name ijms-23-08979-i002.jpg inhibition of caspase-1 activation, IL-1β secretion, and ASC aggregation
  • -

    APP/PS1 AD mouse model [117]

  • -

    TgCRND8 AD mouse model [118]
VX-765
(also known as Belnacasan)		 N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(2R,3S)-2-ethoxytetrahydro-5-oxo-3-furanyl]-L-prolinamide graphic file with name ijms-23-08979-i003.jpg inhibition of caspase-1 and caspase-4
  • -

    J20 AD mouse model [119]

  • -

    APPSw/Ind J20 and wild-type AD mouse model [120]
OLT1177
(also known as Dapansutrile)		 3-(Methane sulfonyl)propanenitrile graphic file with name ijms-23-08979-i004.jpg inhibition of NLRP-ASC and NLRP3-caspase-1 interaction
  • -

    APP/PS1 AD mouse model [127]