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MALDI spectra corresponding to products of H4 histone (0.8 mg/mL) hydrolysis in the presence of IgGs against MBP ((A–D) 0.045 mg/mL) at zero time of the experiment ((A) Con-0d-MBP), after spontaneous development of EAE during 60 days ((B) Con-60d-MBP), 60 days after mouse immunization with DNA–histones complex ((C) DNA-60d-MBP), and 20 days after mouse treatment with MOG ((D) MOG-20d-MBP).
