Table 1.

miRNA expression in sepsis-related brain dysfunction.

Author and Reference	Year of Publication	Sepsis Model	Brief Description of miRNAs in Sepsis-Induced Brain Injury
Dong et al. [19]	2019	In vivo	miR-181b is downregulated in hippocampus
Yu et al. [21]	2019	In vitro	miR-200a-3p upregulation induced inflammatory response in sepsis-induced brain injury
Chen et al. [20]	2020	In vivo	miR-181b is overexpressed in septic cerebral cortex
Visitchanakun et al. [22]	2020	In vivo	miR-370-3p overexpression in SAE (in brain tissue and blood) miR-370-3p associated with TNF-α and increased brain apoptosis in SAE mice
Kim et al. [23]	2021	In vivo	miR-147 is downregulated in brain compared to other organ and also compared to controls
Nong et al. [24]	2021	In vivo	miR-126 downregulation is related to a protective role against sepsis-related blood–brain barrier damage
Rani et al. [25]	2022	In vivo	miR-190a-3p, let-7a-1-3p, miR-3085-3p were overexpressed in young and older females on day 1; miR-383-5p was instead downregulated in young males and females on day 4
Zou et al. [26]	2022	In vivo In vitro	miR-146a induces CXCL2 in microglia and reduces CXCL” in astrocytes miR-146a knock-out is related to low levels of neutrophils and monocytes in brain tissue