Table 3.
miRNA expression in blood during sepsis.
| Author and Reference |
Year of Publication |
Sepsis Model | Brief Description of miRNAs in Blood during Sepsis |
|---|---|---|---|
| Wang et al. [113] | 2019 | In vivo | miR-494-3p was downregulated; upregulation reduced inflammation through reduction in TNF-α levels and reduction in NF-κB p65 nuclear translocation |
| Li et al. [114] | 2018 | In vivo In vitro |
miR-218 was downregulated; upregulation reduced inflammation |
| Zhou et al. [115] | 2018 | In vivo | miR-218 was downregulated; upregulation reduced inflammation |
| Abou El-Khier NT et al. [116] | 2018 | In vivo In vitro |
miR-122 was upregulated, and can be used as a prognostic biomarker for sepsis |
| Sun et al. [117] | 2020 | In vivo | miR-328 was upregulated; downregulation reduced inflammation. Its expression was a good diagnostic marker for sepsis |
| Na et al. [118] | 2020 | In vivo In vitro |
miR-21 was downregulated, representing a good predictor for sepsis risk |
| Lin et al. [119] | 2020 | In vivo | miR-126 was upregulated, representing a good marker for sepsis |
| Li et al. [120] | 2020 | In vivo | miR-125a was upregulated, representing a good marker for sepsis |
| Song et al. [121] | 2017 | In vivo In vitro |
miR-146a was upregulated, upregulation improved survival in septic mice. It represents a good biomarker and predictor for high sepsis risk |
| Chen et al. [122] | 2020 | In vivo | miR-146a was upregulated; upregulation was associated with increased inflammation. It represents a good biomarker and predictor for high sepsis risk |
| Bai et al. [123] | 2018 | In vivo | miR-146a was upregulated; upregulation improved survival in septic mice. It represents a good biomarker and predictor for high sepsis risk |
| Brudecki et al. [124] | 2013 | In vivo In vitro |
miR-146a was upregulated; upregulation improved survival in septic mice. It represents a good biomarker and predictor for high sepsis risk |
| Banarjee et al. [125] | 2013 | In vivo In vitro |
miR-146a was upregulated; upregulation improved survival in septic mice. It represents a good biomarker and predictor for high sepsis risk |
| Mohnle et al. [126] | 2015 | In vivo In vitro |
miR-146a was downregulated; downregulation induced inflammation |
| Paik et al. [127] | 2019 | In vivo | miR-146a was downregulated; downregulation induced inflammation |
| Chen et al. [122] | 2020 | In vivo | miR-146b was upregulated; upregulation was associated with increased inflammation. It represents a good biomarker and predictor for high sepsis risk |
| Zhang et al. [128] | 2020 | In vivo | miR-146b was upregulated; upregulation reduced inflammation |
| Gao et al. [129] | 2017 | In vivo | miR-146b was upregulated; upregulation reduced inflammation |
| Zou et al. [130] | 2020 | In vivo | miR-126 was upregulated, representing a good marker for sepsis |
| Dang et al. [131] | 2020 | In vivo In vitro |
miR-223 was expressed in sepsis; upregulation reduced severity of sepsis |
| Yao et al. [132] | 2015 | In vivo | miR-25 upregulation reduced oxidative stress |
| Xue et al. [133] | 2019 | In vivo In vitro |
miR-21 was upregulated; downregulation reduced inflammation |
| Liu et al. [56] | 2020 | In vivo | miR-223 was downregulated; represents a good biomarker for sepsis |
| Benz et al. [134] | 2015 | In vivo | miR-223 serum levels not correlated with sepsis, either in mouse models or in human patients. |
| Wu et al. [135] | 2018 | In vivo | miR-223 was upregulated; upregulation was associated with disease severity and inflammation |
| Zhou et al. [136] | 2016 | In vivo In vitro |
miR-205-5b was downregulated with increased HMGB1 expression and inflammation |
| Wu et al. [137] | 2020 | In vivo In vitro |
miR-145a was downregulated; upregulation reduced inflammation |
| Ma et al. [138] | 2019 | In vivo In vitro |
miR-145a was downregulated; upregulation reduced inflammation |
| Cao et al. [139] | 2019 | In vivo In vitro |
miR-145a was downregulated; upregulation reduced inflammation |
| Pan et al. [140] | 2018 | In vivo In vitro |
miR-145a was downregulated; upregulation reduced inflammation |
| Zhao et al. [120] | 2020 | In vivo | miR-125b was upregulated; it is a marker of sepsis and risk of mortality |
| Sisti et al. [141] | 2018 | In vivo In vitro |
miR-125b was upregulated; it is a marker of sepsis and risk of mortality |
| Zhu et al. [142] | 2020 | In vivo | miR-125b was upregulated; it is a marker of sepsis and risk of mortality |
| Sun et al. [143] | 2021 | In vivo In vitro |
miR-27b was downregulated; upregulation reduced levels of inflammation |
| Sisti et al. [141] | 2018 | In vivo In vitro |
miR-203b was downregulated; its expression reduced inflammation |
| Zheng et al. [144] | 2020 | In vivo In vitro |
miR-10 a was downregulated; its expression was associated with disease’s severity scores |
| Liu et al. [145] | 2015 | In vivo | miR-155 was upregulated; upregulation was associated with severity of disease |
| Zhang et al. [146] | 2019 | In vivo | miR-7110-5p was upregulated, representing a good biomarker for sepsis |
| Jiang et al. [147] | 2015 | In vivo In vitro |
miR-19a was upregulated, upregulation determined an increase in BCR signaling. Downregulation promoted the expression of CD22 |
| Xu et al. [148] | 2020 | In vivo In vitro |
miR-19b-3p was downregulated; upregulation reduced inflammation |
| Liu et al. [149] | 2021 | In vivo In vitro |
miR-150 was downregulated; upregulation reduced inflammation |
| Sheng et al. [150] | 2017 | In vivo | miR-375 was downregulated; upregulation reduced inflammation |
| McClure et al. [151] | 2014 | In vivo | miR-21 and miR-181b were upregulated; downregulation reduced immunosuppression and improved bacterial clearance |
| McClure et al. [152] | 2017 | In vivo | miR-21 and miR-181b were upregulated; downregulation reduced immunosuppression and improved bacterial clearance |
| Han et al. [153] | 2016 | In vivo | miR-143 was upregulated, representing a good marker for sepsis |
| Liu et al. [154] | 2020 | In vivo In vitro |
miR-20b-5p was upregulated; downregulation reduced inflammation |
| Ji et al. [155] | 2019 | In vivo In vitro |
miR-17-5p was downregulated; upregulation reduced inflammation |
| Szilagyi et al. [156] | 2020 | In vivo | miR-26b was downregulated; downregulation increased inflammation and mortality |
| Chen et al. [157] | 2020 | In vivo In vitro |
miR-96-5p was downregulated; upregulation reduced inflammation |
| Wang et al. [158] | 2014 | In vivo In vitro |
miR-27a was upregulated; downregulation reduced inflammation and promoted survival |
| Yang et al. [159] | 2018 | In vivo | miR-27a was upregulated; downregulation reduced inflammation and promoted survival |
| Wang et al. [43] | 2012 | In vivo | miR-574-5p was upregulated; upregulation increased mortality rate |
| Sun et al. [45] | 2012 | In vivo | miR-181b was downregulated; upregulation reduced inflammation and mortality |
| Yang et al. [160] | 2019 | In vivo In vitro |
miR-346 upregulation promoted proliferation |
| Bai et al. [161] | 2020 | In vivo In vitro |
miR-148a-3p was upregulated; upregulation induced inflammation |
| Zhang et al. [162] | 2019 | In vivo In vitro |
miR-218-5p was upregulated; downregulation improved survival |
| Ma et al. [163] | 2021 | In vivo | miR-1298-5p was upregulated; upregulation reduced inflammation |
| Gu et al. [164] | 2020 | In vitro | miR-608 was upregulated; upregulation reduced inflammation |
| Zhang et al. [165] | 2018 | In vivo | miR-124 was downregulated; upregulation reduced inflammation |
| Huo et al. [166] | 2017 | In vivo | miR-29a was upregulated, and is considered an independent risk factor for mortality in sepsis |
| Cao et al. [167] | 2021 | In vivo In vitro |
miR-155 was upregulated; upregulation induced inflammation |
| Ma et al. [168] | 2017 | In vivo In vitro |
miR-155 was upregulated; upregulation induced inflammation |
| Wang et al. [169] | 2014 | In vivo | miR-30a was downregulated; upregulation reduced inflammation |
| Mei et al. [170] | 2019 | In vivo In vitro |
miR-339-5p was downregulated; upregulation reduced inflammation |
| Wang et al. [171] | 2016 | In vivo | miR-99b was upregulated |
| Yao et al. [172] | 2020 | In vitro | miR-215-5p was downregulated; upregulation reduced inflammatory response |
| Wang et al. [173] | 2012 | In vivo In vitro |
miR-15a was upregulated, and is useful to distinguish sepsis from SIRS |
| Liang et al. [174] | 2020 | In vivo In vitro |
miR-206 was upregulated, and is considered a good biomarker for sepsis |
| Wang et al. [175] | 2020 | In vivo | miR-92a-3p was downregulated; upregulation induced inflammation |