Table 8.

miRNAs involved in sepsis-induced heart dysfunction and their targets. ↑ indicates up regulation, ↓ indicates down regulation.

miRNA	Target Gene/Pathway	Upregulation/Downregulation and Its Effect on Heart Function	Author and Reference
miR-223	STAT3 Sema3A	↓miR-223 ↑STAT3 and Sema3A ↓Cardiac function	Wang et al. [54]
miR-223	FOXO1	↑miR-223 ↓FOXO1 ↑Cardiac function	Liu et al. [56]
miR-223	NF-κB	↑miR-223 ↑NF-κB -	M’baya-Moutoula et al. [57]
miR-27a	Nrf2	↑miR-27a ↑Nrf2 ↓Cardiac function	Xue et al. [58]
miR-146a	ICAM1 VCAM1	↑miR-146a ↓ICAM1 and VCAM1 ↑Cardiac function	Gao et al. [60]
miR-146a	TRAF6 IRAK1	↑miR-146a ↓ TRAF6 and IRAK1 ↑Cardiac function	An et al. [61]
miR-146a	TRAF6 IRAK1	↑miR-146a ↓TRAF6 and IRAK1 ↑Cardiac function	Xie et al. [62]
miR-146b	Notch1	↑miR-146b ↓Notch1 ↑Cardiac function	Wang et al. [63]
miR-125b	TRAF6	↓miR-125b ↑TRAF6 ↑Cardiac function	Ma et al. [64]
miR-150-5p	-	↓miR-150-5p - ↓Cardiac function	Wei et al. [65]
miR-150-5p	Akt2	↓miR-150-5p ↑Akt2 ↓Cardiac function	Zhu et al. [66]
miR-21-3p	SORBS2	↑miR-21-3p ↓SORBS2 ↓Cardiac function	Wang et al. [67]
miR-155	Pea15a	↓miR-155 ↑Pea15a ↑Cardiac function	Wang et al. [68]
miR-155	Arrb2	↑miR-155 ↓Arrb2 ↑Cardiac function	Zhou et al. [71]
miR-124a	STX2	↑miR-124 ↓STX2 ↑Cardiac function	Diao et al.. [69]
miR-135a	-	↑miR-135a - ↓Cardiac function	Zheng et al. [70]
miR-214	PTEN	↑miR-214 ↑PTEN ↑Cardiac function	Ge et al. [72]
miR-214-3p	PTEN	↑miR-214-3p ↓PTEN ↑Cardiac function	Sang et al. [73]
miR-874	AQP1	↑miR-874 ↓AQP1 ↓Cardiac function	Fang et al. [74]
miR-93-3p	TLR4	↑miR-93-3p ↓TLR4 ↑Cardiac function	Tang et al. [78]
miR-25	PTEN	↑miR-25 ↓PTEN ↑Cardiac function	Yao et al. [79]
miR-494-3p	PTEN	↑miR-494-3p ↓PTEN ↑Cardiac function	Wu et al. [80]
miR-23b	TGIF1 PTEN	↑miR-23b ↓TGIF1 and PTEN ↑Cardiac function	Zhang et al. [81]
miR-23b	TRAF6 IKKβ	↑miR-23b ↓TRAF6 and IKKβ ↑Cardiac function	Cao et al. [84]
miR-495	-	↑miR-495- ↑Cardiac function	Guo et al. [85]
miR-98	HMGA2	↑miR-98 ↓HMGA2 ↑Cardiac function	Zhu et al. [86]
miR-208-5p	SOCS2	↑miR-208-5p ↓SOCS2 ↓Cardiac function	Ouyang et al. [87]
miR-328	-	↑miR-328 - ↓Cardiac function	Sun et al. [88]
miR-29a	SIRT1	↑miR-29a ↑Cardiac function	Zhu et al. [91]
miR-29a	-	↑miR-29a ↑Cardiac function	Song et al. [92]
miR-24	XIAP	↑miR-24 ↓XIAP ↓Cardiac function	Chen et al. [93]
miR-192-5p	XIAP	↓miR-192-5p ↑XIAP ↑Cardiac function	Sun et al. [94]
miR-144-3p	-	↑miR-144-3p ↑Cardiac function	Wei et al. [95]
miR-330-5p	TRAF6	↑miR-330-5p ↓TRAF6 ↑Cardiac function	Xing et al. [96]
miR-1-5p	HSPA4	↓miR-1-5p ↑HSPA4 ↑Cardiac function	Han et al. [97]
miR-29b-3p	FOXO3A	↑miR-29b-3p ↓FOXO3A ↑Cardiac function	Li et al. [98]
miR-101-3p	DUSP1	↓miR-101-3p ↑DUSP1 ↑Cardiac function	Xin et al. [99]
miR-106b-5p	PTENP1	↑miR-106b-5p ↓PTENP1 ↑Cardiac function	Liu et al. [100]
miR-29c-3p	-	↑miR-29c-3p ↓Cardiac function	Zhang et al. [101]
miR-499a-5p	EIF4E	↑miR-499a-5p ↓EIF4E ↑Cardiac function	Yang et al. [102]