Table 9.
miRNAs involved in sepsis-induced inflammation and their targets in blood. ↑ indicates up regulation, ↓ indicates down regulation.
| miRNA | Target Gene/Pathway |
Upregulation/Downregulation and Its Effect on Inflammation Function |
Author and Reference |
|---|---|---|---|
| miR-494-3p | TLR6 | ↓miR-494-3p ↓NF-κB ↑Inflammation |
Wang et al. [113] |
| miR-218 | VOPP1 | ↓miR-218 ↓VOPP1 ↑Inflammation |
Li et al. [114] |
| miR-218 | RUNX2 | ↓miR-218 ↑RUNX2 ↑Inflammation |
Zhou et al. [115] |
| miR-122 | - | ↑miR-122 ↑Inflammation |
Abou El-Khier NT et al. [116] |
| miR-328 | - | ↑miR-328 ↑Inflammation |
Sun et al. [117] |
| miR-21 | - | ↓miR-21 ↑Inflammation |
Na et al. [118] |
| miR-126 | EGFL7 | ↑miR-126 ↑Inflammation |
Lin et al. [119] |
| miR-125a | - | ↑miR-125a ↑Inflammation |
Li et al. [120] |
| miR-146a | - | ↓miR-146a ↑Inflammation |
Song et al. [121] |
| miR-146a | NF-κB | ↑miR-146a ↓NF-κB ↓Inflammation |
Chen et al. [122] |
| miR-146a | Notch1 | ↑miR-146a ↓Notch1 ↓Inflammation |
Bai et al. [123] |
| miR-146a | p38 MAPK | ↑miR-146a ↓p38 MAPK ↓Inflammation |
Brudecki et al. [124] |
| miR-146a | IRAK1 TRAF6 |
↑miR-146a ↓IRAK1/TRAF6 ↓Inflammation |
Banarjee et al. [125] |
| miR-146a | STAT4 | ↓miR-146a ↑PRKCε/STAT4 ↑Inflammation |
Mohnle et al. [126] |
| miR-146a | - | ↑miR-146a ↓Inflammation |
Paik et al. [127] |
| miR-146b | p38 MAPK | ↑miR-146b ↓p38 MAPK ↓Inflammation |
Chen et al. [122] |
| miR-146b | - | ↑miR-146b ↑Inflammation |
Zhang et al. [128] |
| miR-146b | NF-κB | ↓miR-146b ↑NF-κB ↑Inflammation |
Gao et al. [129] |
| miR-126 | CASP3 | ↑miR-126 ↑CASP3 ↓Mortality |
Zou et al. [130] |
| miR-223 | HIF-1α | ↑miR-223 ↓HIF-1α ↓Inflammation |
Dang et al. [131] |
| miR-25 | NOX4 | ↓miR-25 ↑NOX4 ↑Inflammation |
Yao et al. [132] |
| miR-21 | NLRP3 NF-κB TNFAIP3 |
↑miR-21 ↑NLRP3 ↑NF-κB ↓TNFAIP3 ↑Inflammation |
Xue et al. [133] |
| miR-223 | FOXO1 | ↑miR-223 ↓FOXO1 ↑Inflammation |
Liu et al. [56] |
| miR-223 | - | ↑miR-223 ↑Inflammation |
Wu et al. [135] |
| miR-205 | HMGB1 | ↑miR-205 ↓HMGB1 ↓Inflammation |
Zhou et al. [136] |
| miR-145a | Fli-1/ NF-κB | ↑miR-145a ↓Fli-1/ NF-κB ↓Inflammation |
Wu et al. [137] |
| miR-145a | TGF-β2 | ↓miR-145a ↑TGF-β2 ↑Inflammation |
Ma et al. [138] |
| miR-145a | TGF-β2 | ↓miR-145a ↑TGF-β2 ↑Inflammation |
Cao et al. [139] |
| miR-145a | - | ↑JMJD3 ↓miR-145a ↑Inflammation |
Pan et al. [140] |
| miR-125b | - | ↑miR-125b ↑Inflammation |
Zhao et al. [120] |
| miR-125b | PTEN/MyD88 | ↑miR-125b ↑PTEN ↓MyD88 ↓Inflammation |
Sisti et al. [141] |
| miR-125b | - | ↑miR-125b ↑Inflammation |
Zhu et al. [142] |
| miR-27b | NF-κB | ↑miR-27b ↓NF-κB ↓Inflammation |
Sun et al. [143] |
| miR-203b | PTEN/MyD88 | ↑miR-203b ↑PTEN ↓MyD88 ↓Inflammation |
Sisti et al. [141] |
| miR-10a | MAP3K7/ NF-κB | ↓miR-10a ↑MAP3K7/ NF-κB ↑Inflammation |
Zheng et al. [144] |
| miR-155 | - | ↑miR-155 ↑Inflammation |
Liu et al. [145] |
| miR-7110-5p | - | ↑miR-7110-5p ↑Inflammation |
Zhang et al. [146] |
| miR-19a | - | ↑miR-19a ↑Inflammation |
Jiang et al. [147] |
| miR-19b-3p | - | ↑miR-19b-3p ↓Inflammation |
Xu et al. [148] |
| miR-150 | ARG1 | ↑miR-150 ↓ARG1 ↓Inflammation |
Liu et al. [149] |
| miR-375 | JAK2-STAT3 | ↑miR-375 ↓JAK2-STAT3 ↓Inflammation |
Sheng et al. [150] |
| miR-21 miR-181b |
NFI-A | ↓miR-21 and miR-181b ↓NFI-A ↓Inflammation |
McClure et al. [151] |
| miR-21 miR-181b |
STAT3 and C/EBPβ | ↓miR-21 and miR-181b ↓STAT3 and C/EBPβ ↓Inflammation |
McClure et al. [152] |
| miR-143 | - | ↑miR-143 ↑Inflammation |
Han et al. [153] |
| miR-20b-5p | - | ↑circDNMT3B ↓miR-20b-5p ↓Inflammation |
Liu et al. [154] |
| miR-17-5p | TLR4 | ↑miR-17-5p ↓TLR4 ↓Inflammation |
Ji et al. [155] |
| miR-26b | SELP | ↓miR-26b ↑SELP ↑Inflammation |
Szilagyi et al. [156] |
| miR-96-5p | NAMPT | ↑miR-96-5p ↓NAMPT ↓Inflammation |
Chen et al. [157] |
| miR-27a | PPAR γ | ↓miR-27a ↑PPAR γ ↓Inflammation |
Wang et al. [158] |
| miR-27a | TAB3 | ↓miR-27a ↑TAB3 ↓Inflammation |
Yang et al. [159] |
| miR-574-5p | - | ↑miR-574-5p ↑Inflammation |
Wang et al. [43] |
| miR-181b | Importin-α3 NFkβ |
↑miR-181b ↓Importin-α3 and NFkβ ↓Inflammation function |
Sun et al. [45] |
| miR-346 | SMAD3 | ↑miR-346 ↓SMAD3 ↑Inflammation |
Yang et al. [160] |
| miR-148a-3p | Notch1 | ↑miR-148a-3p ↑Notch1 ↑Inflammation |
Bai et al. [161] |
| miR-218-5p | HO-1 | ↓miR-218-5p ↑HO-1 ↓Inflammation |
Zhang et al. [162] |
| miR-1298-5p | SOCS6 | ↓miR-1298-5p ↓STAT3 ↓inflammation |
Ma et al. [163] |
| miR-608 | ELANE | ↑miR-608 ↓Inflammation |
Gu et al. [164] |
| miR-124 | - | ↓miR-124 ↑Inflammation |
Zhang et al. [165] |
| miR-29a | - | ↑miR-29a ↑Inflammation |
Huo et al. [166] |
| miR-155 | NF-κB | ↑miR-155 ↓NF-κB ↑Inflammation |
Cao et al. [167] |
| miR-155 | - | ↑miR-155 ↑Inflammation |
Ma et al. [168] |
| miR-30a | MD-2 | ↑miR-30a ↓MD-2 ↑Inflammation |
Wang et al. [169] |
| miR-339-5p | HMGB1 | ↑miR-339-5p ↓HMGB1 ↓Inflammation |
Mei et al. [170] |
| miR-99b | MFG-E8 | ↑miR-99b ↓MFG-E8 ↑Inflammation |
Wang et al. [171] |
| miR-215-5p | ILF3 and LRRFIP1 | ↓miR-215-5p ↑ILF3 and LRRFIP1 ↑Inflammation |
Yao et al. [172] |
| miR-15a | - | ↑miR-15a ↑Inflammation |
Wang et al. [173] |
| miR-206 | - | ↑miR-206 ↑Inflammation |
Liang et al. [174] |
| miR-92a-3p | LCN2 | ↓miR-92a-3p ↓LCN2 ↓Inflammation |
Wang et al. [175] |