Table 10.

miRNAs involved in sepsis-induced lung dysfunction and their targets. ↑ indicates up regulation, ↓ indicates down regulation.

miRNA	Target Gene/Pathway	Upregulation/Downregulation and Its Effect on Lung Function	Author and Reference
miR-155	TAB2	↑miR-155 ↓TAB2 ↑Pulmonary function	Liu et al. [191]
miR-155	SHIP1 SOCS1	↑miR-155 ↓SHIP1 and SOCS1 ↓Pulmonary function	Jiang et al. [192]
miR-155	TREM1	↑miR-155 ↑TREM1 ↓Pulmonary function	Yuan et al. [193]
miR-155	IRF2BP2	↑miR-155 ↓IRF2BP2 ↓Pulmonary function	Li et al. [195]
miR-155	-	↓miR-155 - -	Han et al. [196]
miR-146	Akt2	↑miR-146 ↓Akt2 ↑Pulmonary function	Vergadi et al. [197]
miR-146	IRAK1 TRAF6	↑miR-146 ↓IRAK1 and TRAF6 ↑Pulmonary function	Zeng et al. [198]
miR-144-3p	CAV2	↑miR-144-3p ↓CAV2 ↓Pulmonary function	Xu et al. [199]
miR-19a-3p	USP13	↑miR-19a-3p ↓USP13 ↓Pulmonary function	Ren et al. [200]
miR-199a	SIRT1	↓miR-199a ↑SIRT1 ↑Pulmonary function	Liu et al. [201]
miR-34a	SIRT1 ATG4B	↓miR-34a ↑SIRT1 and ATG4B ↑Pulmonary function	Chen et al. [202]
miR-34b-5p	TUG1	↓miR-34b-5p ↑TUG1 ↑Pulmonary function	Qiu et al. [221]
miR-132	SIRT1	↑miR-132 ↓SIRT1 ↓Pulmonary function	Zhu et al. [203]
miR-30d-5p	SIRT1 SOCS1	↑miR-30d-5p ↑SIRT1 and SOCS1 ↓Pulmonary function	Jiao et al. [204]
miR-1298-5p	SOCS6	↑miR-1298-5p ↓SOCS6 ↓Pulmonary function	Ma et al. [226]
miR-92a-3p	AKAP1	↑miR-92a-3p ↓AKAP1 ↓Pulmonary function	Wang et al. [205]
miR-23a	PTEN	↑miR-23a ↓PTEN ↑Pulmonary function	Yang et al. [206]
miR-218	RUNX2	↑miR-218 ↓RUNX2 ↑Pulmonary function	Zhou et al. [227]
miR-539-5p	ROCK1	↑miR-539-5p ↓ROCK1 ↑Pulmonary function	Meng et al. [207]
miR-145	TGF-β2	↓miR-145 ↑TGF-β2 ↓Pulmonary function	Cao et al. [139]
miR-124	MAPK14	↓miR-124 ↑MAPK14 ↓Pulmonary function	Pan et al. [208]
miR-483-5p	PIAS1	↑miR-483-5p ↓PIAS1 ↓Pulmonary function	Leng et al. [209]
miR-497-5p	IL2RB	↓miR-497-5p ↑IL2RB ↑Pulmonary function	Lou et al. [210]
miR-802	Peli2	↑miR-802 ↓Peli2 ↑Pulmonary function	You et al. [211]
miR-326	TLR4	↑miR-326 ↓TLR4 ↑Pulmonary function	Wang et al. [212]
miR-129-5p	HMGB1	↑miR-129-5p ↓HMGB1 ↑Pulmonary function	Yang et al. [213]
miR-129	TAK1	↑miR-129 ↓TAK1 ↑Pulmonary function	Yao et al. [215]
miR-490	MRP4	↑miR-490 ↓MRP4 ↑Pulmonary function	Lin et al. [214]
miR-127	CD64	↑miR-127 ↓CD64 ↑Pulmonary function	Xie et al. [216]
miR-125-5p	TOP2A	↑miR-125-5p ↓TOP2A ↑Pulmonary function	Jiang et al. [217]
miR-499-5p	SOX6	↑miR-499-5p ↓SOX6 ↑Pulmonary function	Zhang et al. [218]
miR-942-5p	TRIM37	↑miR-942-5p ↓TRIM37 ↑Pulmonary function	Lu et al. [219]
miR-16-5p	BRD4	↑miR-16-5p ↓BRD4 ↑Pulmonary function	Yin et al. [220]
miR-195-5p	PDK4	↑miR-195-5p ↓PDK4 ↓Pulmonary function	Wang et al. [222]
miR-152-3p	PDK4	↓miR-152-3p ↑PDK4 ↑Pulmonary function	Zhu et al. [223]
miR-128-3p	SIRT1	↑miR-128-3p ↓SIRT1 ↓Pulmonary function	Xie et al. [224]
miR-424	ROCK2	↓miR-424 ↑ROCK2 ↓Pulmonary function	Chen et al. [225]