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The metabolism of Vitamin D. Solid arrows show the direct effects of its products, and dotted lines demonstrate the negative feedback of plasma calcium or 1,25(OH)2D. (Ca: calcium; 7-DHC: 7-dehydrocholesterol; GH: growth hormone; 1a-OHase: 1-alpha-hydroxylase; 25-OHase: 25-hydroxylase; P: phosphate; PTH: parathyroid hormone; VDR: vitamin D receptor; Vit: vitamin).
