Table 3.
Summary statistics for each biomarker separated by different groups.
| Biomarker | Healthy Control | GD-Naïve | GD-Treated |
|---|---|---|---|
| N = 18 | N = 5 | N = 13 | |
| Total_GSH (µg/mL) | |||
| Mean (SD) | 620 (144) | 516 (89) | 483 (114) |
| Median (IQR) | 614 (189) | 509 (122) | 439 (163) |
| Unknown | 6 | 0 | 2 |
| Ratio_GSHGSSG | |||
| Mean (SD) | 29 (17) | 6 (1) | 15 (13) |
| Median (IQR) | 27 (28) | 6 (2) | 10 (15) |
| Unknown | 5 | 0 | 2 |
| CAT_Activity (nmol/min/mL/mg) | |||
| Mean (SD) | 563 (371) | 321 (56) | 245 (94) |
| Median (IQR) | 388 (534) | 326 (71) | 244 (126) |
| Unknown | 4 | 0 | 2 |
| SOD_Activity (U/mL/mg) | |||
| Mean (SD) | 6.01 (3.99) | 4.71 (1.40) | 6.18 (2.64) |
| Median (IQR) | 4.95 (2.69) | 4.43 (1.36) | 5.68 (4.11) |
| Unknown | 4 | 0 | 2 |
| GPx_Activity (nmol/min/mL/mg) | |||
| Mean (SD) | 18.0 (5.8) | 14.1 (4.5) | 15.2 (4.7) |
| Median (IQR) | 19.2 (7.8) | 14.4 (5.7) | 15.0 (5.4) |
| Unknown | 4 | 0 | 2 |
| Protein_Carbonyl (nmol/mg) | |||
| Mean (SD) | 1.55 (2.23) | 0.43 (0.45) | 0.55 (0.35) |
| Median (IQR) | 0.64 (0.80) | 0.27 (0.33) | 0.54 (0.39) |
| Unknown | 4 | 0 | 1 |
| MDA (nM/mg) | |||
| Mean (SD) | 41 (19) | 90 (23) | 68 (29) |
| Median (IQR) | 38 (23) | 88 (17) | 65 (45) |
| Unknown | 4 | 1 | 1 |
| IL1RA (pg/mL) | |||
| Mean (SD) | 255 (106) | 1043 (396) | 694 (458) |
| Median (IQR) | 256 (155) | 1000 (513) | 619 (540) |
| Unknown | 5 | 0 | 1 |
| IL-6 (pg/mL) | |||
| Mean (SD) | 1.82 (1.27) | 2.14 (0.84) | 2.30 (1.30) |
| Median (IQR) | 2.29 (2.25) | 2.08 (0.95) | 2.26 (1.53) |
| Unknown | 5 | 0 | 1 |
| IL-8 (pg/mL) | |||
| Mean (SD) | 2.52 (0.96) | 6.94 (2.53) | 4.65 (3.82) |
| Median (IQR) | 2.56 (0.90) | 7.05 (2.35) | 3.13 (2.52) |
| Unknown | 5 | 0 | 1 |
| MCP1 (pg/mL) | |||
| Mean (SD) | 81 (41) | 90 (33) | 98 (53) |
| Median (IQR) | 68 (43) | 89 (32) | 78 (62) |
| Minimum–Maximum | 32–219 | 31–139 | 45–304 |
| Unknown | 5 | 0 | 1 |
| MIP-1a (pg/mL) | |||
| Mean (SD) | 16 (13) | 17 (35) | 26 (45) |
| Median (IQR) | 15 (22) | 0 (0) | 1 (36) |
| Minimum–Maximum | 0–43 | 0–102 | 0–194 |
| Unknown | 5 | 0 | 1 |
| MIP-1b (pg/mL) | |||
| Mean (SD) | 8 (7) | 87 (53) | 25 (21) |
| Median (IQR) | 7 (11) | 71 (51) | 22 (22) |
| Unknown | 5 | 0 | 1 |
| TNFa (pg/mL) | |||
| Mean (SD) | 0.73 (0.83) | 1.86 (0.98) | 1.40 (0.94) |
| Median (IQR) | 0.27 (1.27) | 1.84 (1.33) | 1.58 (1.35) |
| Unknown | 5 | 0 | 1 |
| IL-10 (U/mL) | |||
| Mean (SD) | 0.34 (0.44) | 0.39 (0.54) | 4.42 (21.41) * |
| Median (IQR) | 0.08 (0.91) | 0.08 (1.00) | 1.02 (1.17) * |
| Unknown | 5 | 0 | 1 |
* When data for one participant from the GD-treated group was omitted, because of apparent outlying measurements, the mean (SD) and median (IQR) were 0.72 (0.62) and 0.94 (1.14), respectively.