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. 2022 Aug 14;23(16):9117. doi: 10.3390/ijms23169117

Table 2.

Biological effects of various types of carrageenans.

CG Used Technique Studied Effects Ref
OKC K-CG oxidation—exposure to NaIO4 (1:0.5 ratio; at 40 °C; for 3 h; at pH 3), crosslinking with PVA and HA (HA:OKC:PVA—0:4:6; 1:3:6; 2:2:6; 3:1:6; 2.5:2.5:5; 3.5:3.5:3). Electrospinning: 5 mL syringe; 22G needle; 0.5 mL/h at 25 ± 2 °C; 10 cm tip-to-collector; 17.5 kV DC voltage Antibacterial properties [77]
K-CG Solvents: distilled H2O, with and without sonication; NaCl solution; crosslinking with fully or partially hydrolyzed PVA (PVA:K-CG 70:30) Drug and nutrient delivery ability [79]
CMKC Crosslinked with PVA; PVA:CMKC—1:0; 1:0.25; 1:0.4; 1:0.5; 1:0.75. Electrospinning: 19G needle; 1 mL/h at 20 ± 2 °C; 15 cm tip-to-collector 15 kV DC voltage Cytocompatibility, biodegradability, cell growth, cell adhesion, adipose-derived stem cells’ response to osteogenic differentiation signals [81]
I-CG Crosslinked with PVA and addition of graphene oxide (PVA:I-CG:GO—95:3:2). Electrospinning: 15 cm tip-to-collector 20 kV DC voltage Wound healing, skin repair, antimicrobial properties [80]
I-CG Crosslinking with polycaprolactone (PCL); PCL:I-CG—100:0; 95:5; 90:10; 85:15; 80:20; 0:100. Electrospinning: 10; 15; 18 cm tip-to-collector 20 kV DC voltage Biocompatibility, bone tissue growth [89]
K-CG Crosslinked with polyhydroxybutyrate (PHB) or polyhydroxybutyrate valerate (PHBV); PHB:K-CG and PHBV:K-CG—100:0; 90:10; 80:20; 70:30. Electrospinning: 1 mLSyringe dispensed at 3.5 mL/h (PHB/K-CG) and 3.0 mL/h (PHBV/K-CG); 15 cm tip-to-collector; 20 kV DC voltage Bone tissue engineering [90]
K-CG Crosslinked with PHB, caffeic acid (CA), and quaternized chitosan (QCh). Electrospinning: 2 mL/h; 15 cm tip-to-collector; 25 kV DC voltage Antimicrobial and antioxidant properties [91]
K-CG Crosslinked with polydioxanone (PDX); PDX:K-CG—100:0; 90:10; 80:20; 70:30. Electrospinning: 6 mL/h; 15 cm tip-to-collector; 25 kV DC voltage Viability and differentiation of SaOS-2 preosteoblasts [92]