Table 1.
Diagnostic accuracy of urinary microRNAs (miRNAs) for bladder cancer (BCa).
| Study | Year | Target (Expression in BCa) |
BCa/Ctl (n) | Primary Findings | Ref. |
|---|---|---|---|---|---|
| Mengual et al. | 2013 | Panel of six miRNAs: | 181/136 | 84.8% SN, 86.5% SP; AUC 0.92 (overall) 77.6% SN, 86.5% SP (low-grade NMIBC) 90.3% SN, 86.5% SP (high-grade NMIBC) 87.1% SN, 86.5% SP (MIBC) |
[38] |
| miR-18a* (↑) | |||||
| miR-25 (↑) | |||||
| miR-140-5p (↓) | |||||
| miR-187 (↑) | |||||
| miR-142-3p (↓) | |||||
| miR-204 (↓) | |||||
| De Long et al. | 2015 | miR-940 (↑) | 85/45 | pT2 or greater, pT1 grade 3 > pT1 grade 1, Ctl | [39] |
| miR-26a (↑) | pT2 or greater > pT1 grade 1; pT1 grade 3 > pT1 grade 1; Ctl > pT1 grade 1 |
||||
| Matsuzaki et al. | 2017 | miR-21-5p (↑) | 6/3 | 72.2% SN, 95.8% SP (overall) | [36] |
| Andreu et al. | 2017 | miR-146 (↑) | 36/9 | Low-grade > high-grade | [40] |
| Ghorbanmehr et al. | 2018 | miR-21-5p (↑) | 45/20 | 84% SN, 59% SP; AUC 0.76 (overall) | [37] |
| miR141-3p (↑) | 71% SN, 71% SP; AUC 0.74 (overall) | ||||
| miR205-5p (↑) | 82% SN, 62% SP; AUC 0.73 (overall) | ||||
| Hofbauer et al. | 2018 | Panel of six miRNAs: | 87/115 | AUC 0.88 (overall) AUC 0.88 (low-grade NMIBC) AUC 0.93 (high-grade NMIBC) AUC 0.91 (MIBC) |
[41] |
| Let-7c (↓) | |||||
| miR-135a (↓) | |||||
| miR-135b (↑) | |||||
| miR-148a (↓) | |||||
| miR-204 (↓) | |||||
| miR-345 (↑) | |||||
| Baumgart et al. | 2019 | miR-146 | 37/0 | grade 3 > grades 1, 2 pTa > pT1 > pT2> pT3–4 |
[42] |
| miR-138-5p | |||||
| Next-Generation Sequencing | |||||
| Pardini et al. | 2018 | Panel of three miRNAs: | 66/48 | AUC 0.70 (overall) AUC 0.73 (low-grade NMIBC) AUC 0.95 (high-grade NMIBC) AUC 0.99 (MIBC) |
[43] |
| let-7c-5p (↑) | |||||
| miR-30a-5p (↑) | |||||
| miR-486-5p (↓) | |||||
| Braicu et al. | 2019 | miR-141-3p (↑) | 23/23 | AUC 0.86 (overall) AUC 0.89 (overall) BCa < Ctl BCa < Ctl BCa > Ctl |
[44] |
| miR-205-5p (↑) | |||||
| miR-139-5p (↓) | |||||
| miR-143-5p (↓) | |||||
| miR-200b-3p (↑) | |||||
| Lin et al. | 2021 | Let-7b-5p (↑) | 180/100 | BCa > Ctl BCa > Ctl BCa > Ctl BCa > Ctl BCa > Ctl |
[45] |
| miR-146a-5p (↑) | |||||
| miR-149-5p (↑) | |||||
| miR-193a-5p (↑) | |||||
| miR-423-5p (↑) | |||||
| Moisoiu et al. | 2022 | Panel of three miRNAs: | 15/16 | AUC 0.84 (miRNA alone) AUC 0.84 (SERS alone) AUC 0.92 (miRNA + SERS) |
[46] |
| miR-34a-5p (↑) | |||||
| miR-205-5p (↑) | |||||
| miR-210-3p (↑) | |||||
Ctl: healthy control participants; SN: sensitivity; SP: specificity; AUC: area under the curve; NMIBC: non-muscle-invasive bladder cancer; MIBC: muscle-invasive bladder cancer; SERS: surface-enhanced Raman spectroscopy.