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. 2022 Aug 17;23(16):9224. doi: 10.3390/ijms23169224

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The PPI network involves common genes analysis of a cluster of membrane proteins of GEMM Pb-Cre4/Pten^f/f PCa. PPI of commonly upregulated genes in mPIN (A), MT (B), and AT (C), and downregulated genes in mPIN (D), MT (E), and AT (F). Analysis using STRING [39] illustrates potential interactions. Proteins in the interaction network are represented as nodes connected by lines whose thickness reflects a confidence index higher than 0.7. mPIN = mouse Prostatic Intraepithelial Neoplasia; MT = Middle-stage tumor; AT = Advanced-stage tumor.