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. 2022 Aug 17;23(16):9224. doi: 10.3390/ijms23169224

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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The PPI network involves common genes analysis of a cluster of secreted proteins of PCa in Pten knockout mice. PPI of commonly upregulated genes in mPIN (A), MT (B), and AT (C), and downregulated genes in mPIN (D), MT (E), and AT (F). Analysis using STRING [39] illustrates potential interactions. Proteins in the interaction network are represented as nodes connected by lines whose thickness reflects a confidence index higher than 0.7. mPIN = mouse Prostatic Intraepithelial Neoplasia; MT = Middle-stage tumor; AT = Advanced-stage tumor.