Table 1.

A gene ontology (GO) enrichment analysis of membrane proteins upregulated in mPIN, MT, and AT of prostate cancer.

mPIN Upregulated Gene Ontology (GO)
Pathway ID	Pathway Description	Gene Count	Adjusted p-Value	Log10
GO:0005887	Integral component of plasma membrane	32	1.73 × 10−11	10.76299509
GO:0004713	Protein tyrosine kinase activity	5	0.012138352	1.915840284
GO:0016758	Hexosyltransferase activity	5	0.014297294	1.844746144
GO:0043190	ATP-binding cassette (ABC) transporter complex	2	0.019180885	1.717131357
GO:0008194	UDP-glycosyltransferase activity	4	0.024662147	1.607969117
GO:0009312	Oligosaccharide biosynthetic process	3	0.034162979	1.466444268
GO:0016051	Carbohydrate biosynthetic process	3	0.034162979	1.466444268
GO:0019375	Galactolipid biosynthetic process	2	0.034162979	1.466444268
GO:0006682	Galactosylceramide biosynthetic process	2	0.034162979	1.466444268
GO:0046476	Glycosylceramide biosynthetic process	2	0.0382352	1.417536631
GO:0006681	Galactosylceramide metabolic process	2	0.041917255	1.377607169
GO:0030165	PDZ domain binding	3	0.048747995	1.31204324
MT Upregulated Gene Ontology (GO)
Pathway ID	Pathway Description	Gene Count	Adjusted p-Value	Log10
GO:0005887	Integral component of plasma membrane	43	9.77 × 10−17	16.01024386
GO:0016323	Basolateral plasma membrane	10	0.00000211	5.675736848
GO:0004713	Protein tyrosine kinase activity	7	0.001099549	2.9587853
GO:0019199	Transmembrane receptor protein kinase activity	5	0.002610742	2.5832361
GO:0004714	Transmembrane receptor protein tyrosine kinase activity	5	0.002610742	2.5832361
GO:0005254	Chloride channel activity	5	0.00268003	2.571860416
GO:0045121	Membrane raft	7	0.002867281	2.542529695
GO:0043005	Neuron projection	11	0.01394385	1.855617311
GO:0007167	Enzyme linked receptor protein signaling pathway	7	0.024380271	1.612961464
AT Upregulated Gene Ontology (GO)
Pathway ID	Pathway Description	Gene Count	Adjusted p-Value	Log10
GO:0005887	Integral component of plasma membrane	46	1.74 × 10−17	16.75829697
GO:0030667	Secretory granule membrane	13	0.00000273	5.564593362
GO:0006954	Inflammatory response	11	0.000308	3.511189697
GO:0071345	Cellular response to cytokine stimulus	15	0.000421	3.375939369
GO:0002283	Neutrophil activation involved in immune response	13	0.00509802	2.292598474
GO:0004713	Protein tyrosine kinase activity	6	0.00518138	2.285554596
GO:0070372	Regulation of ERK1 and ERK2 cascade	9	0.005657676	2.247361946
GO:0032103	Positive regulation of response to external stimulus	7	0.006311353	2.199877562
GO:0043410	Positive regulation of MAPK cascade	9	0.008909311	2.050155885
GO:0030198	Extracellular matrix organization	9	0.012342256	1.908605459
GO:0005925	Focal adhesion	9	0.013649783	1.864874257
GO:0005789	Endoplasmic reticulum membrane	12	0.028337729	1.547634959