Table 2.

A gene ontology (GO) enrichment analysis of secreted proteins upregulated in mPIN, MT, and AT of prostate cancer.

mPIN Upregulated Gene Ontology (GO)
Pathway ID	Pathway Description	Gene Count	Adjusted p-Value	Log10
GO:0019221	Cytokine-mediated signaling pathway	10	0.0000154	4.813747101
GO:0062023	Collagen-containing extracellular matrix	7	0.0000354	4.451038902
GO:0016019	Peptidoglycan immune receptor activity	2	0.000428	3.368891105
GO:1902533	Positive regulation of intracellular signal transduction	7	0.001214858	2.915474599
GO:0042834	Peptidoglycan binding	2	0.002962979	2.528271463
GO:0008284	Positive regulation of cell population proliferation	6	0.003344125	2.475717449
GO:0001774	Microglial cell activation	2	0.008863214	2.052408777
GO:0030855	Epithelial cell differentiation	3	0.008882339	2.051472641
GO:0033628	Regulation of cell adhesion mediated by integrin	2	0.01496553	1.824907884
GO:0030198	Extracellular matrix organization	4	0.01496553	1.824907884
GO:0010811	Positive regulation of cell-substrate adhesion	2	0.037254018	1.428826881
GO:0060252	Positive regulation of glial cell proliferation	1	0.04201877	1.376556662
GO:0033631	Cell-cell adhesion mediated by integrin	1	0.04201877	1.376556662
GO:0071902	positive regulation of protein serine/threonine kinase activity	2	0.046363298	1.333825674
MT Upregulated Gene Ontology (GO)
Pathway ID	Pathway Description	Gene Count	Adjusted p-Value	Log10
GO:0034774	Secretory granule lumen	14	4.44 × 10−12	11.35278878
GO:0006954	Inflammatory response	13	2.06 × 10−11	10.6853178
GO:0062023	Collagen-containing extracellular matrix	12	9.21 × 10−9	8.035890283
GO:1905517	Macrophage migration	3	0.000185	3.732564754
GO:0007160	Cell-matrix adhesion	3	0.011210456	1.950376724
GO:0030855	Epithelial cell differentiation	3	0.011480631	1.940034241
GO:0098632	Cell-cell adhesion mediator activity	2	0.025492739	1.5935835
GO:0030203	Glycosaminoglycan metabolic process	2	0.031920127	1.495935395
GO:0045545	Syndecan binding	1	0.045268101	1.344207727
GO:0048708	Astrocyte differentiation	1	0.048279814	1.316234416
GO:0008347	Glial cell migration	1	0.048279814	1.316234416
AT Upregulated Gene Ontology (GO)
Pathway ID	Pathway Description	Gene Count	Adjusted p-Value	Log10
GO:0048018	Receptor ligand activity	19	3.70 × 10−18	17.43149267
GO:0019221	Cytokine-mediated signaling pathway	23	5.23 × 10−16	15.28185137
GO:0006954	Inflammatory response	15	1.64 × 10−13	12.78451214
GO:0062023	Collagen-containing extracellular matrix	13	1.23 × 10−8	7.90940544
GO:0008284	Positive regulation of cell population proliferation	13	2.40 × 10−7	6.620158329
GO:0070374	Positive regulation of ERK1 and ERK2 cascade	9	3.14 × 10−7	6.503756602
GO:0030198	Extracellular matrix organization	7	0.0000857	4.066941739
GO:0000165	MAPK cascade	7	0.0000906	4.043108741
GO:1905517	Macrophage migration	2	0.000194	3.712020847
GO:0043062	Extracellular structure organization	5	0.000676	3.170015558
GO:0042834	Peptidoglycan binding	1	0.006637813	2.177975013