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. 2022 Aug 17;23(16):9224. doi: 10.3390/ijms23169224

Table 3.

A gene ontology (GO) enrichment analysis of membrane proteins downregulated in mPIN, MT, and AT of prostate cancer.

mPIN Downregulated Gene Ontology (GO)
Pathway ID Pathway Description Gene Count Adjusted p-Value Log10
GO:0098662 Inorganic cation transmembrane transport 11 2.10 × 10−8 7.677498224
GO:0005887 Integral component of plasma membrane 19 2.38 × 10−8 7.623546608
GO:0016529 Sarcoplasmic reticulum 6 3.99 × 10−8 7.399562462
GO:0042383 Sarcolemma 6 6.56 × 10−8 7.18327432
GO:0051480 Regulation of cytosolic calcium ion concentration 8 3.05 × 10−7 6.516291269
GO:0006874 Cellular calcium ion homeostasis 7 0.00000312 5.505384291
GO:0070588 Calcium ion transmembrane transport 5 0.0000635 4.197087214
GO:0005267 Potassium channel activity 4 0.002683985 2.571219909
GO:0005217 Intracellular ligand-gated ion channel activity 2 0.004871735 2.312316306
GO:0006939 Smooth muscle contraction 2 0.005857764 2.232268112
GO:0005790 Smooth endoplasmic reticulum 2 0.007141408 2.146216169
GO:0015081 Sodium ion transmembrane transporter activity 2 0.017072923 1.76769213
MT Downregulated Gene Ontology (GO)
Pathway ID Pathway Description Gene Count Adjusted p-Value Log10
GO:0005267 Potassium channel activity 9 3.84 × 10−9 8.415844939
GO:0006813 Potassium ion transport 10 8.24 × 10−9 8.084282366
GO:0016529 Sarcoplasmic reticulum 7 9.40 × 10−9 8.027036253
GO:0005887 Integral component of plasma membrane 20 0.00000197 5.704434553
GO:0005789 Endoplasmic reticulum membrane 11 0.000418 3.37836809
GO:0015085 Calcium ion transmembrane transporter activity 3 0.010602036 1.974610737
GO:0005790 Smooth endoplasmic reticulum 2 0.018509381 1.732608106
GO:0005355 Glucose transmembrane transporter activity 2 0.019938461 1.700308368
AT Downregulated Gene Ontology (GO)
Pathway ID Pathway Description Gene Count Adjusted p-Value Log10
GO:0005887 Integral component of plasma membrane 25 2.28 × 10−10 9.642075486
GO:0098662 Inorganic cation transmembrane transport 13 1.98 × 10−9 8.703210974
GO:0006813 Potassium ion transport 10 2.03 × 10−9 8.693400143
GO:0010232 Vascular transport 6 0.0000439 4.357272375
GO:0035725 Sodium ion transmembrane transport 6 0.0000439 4.357272375
GO:0005267 Potassium channel activity 6 0.0001 3.999508817
GO:0016529 Sarcoplasmic reticulum 4 0.000734 3.134317147
GO:0015079 Potassium ion transmembrane transporter activity 3 0.003470428 2.459616983