Figure 2.

Structure of Human DNMT3B isoforms. Splice variants isoforms of DNMT3B have different characters. DNMT3B isoforms variates mammalians. Amino and carboxyl-terminal domains variates. DNMT3B isoforms’ nuclear location variates during embryonic development and in tissue specificity. Moreover, it has been found that DNMT3B isoform variates in cancer with their own origin tissue. Suggesting that DNMT3B isoforms have an important role in cancer development. Abbreviatures: motif of interaction with pro-trp-trp-pro (PWWP), and ATRX, DNMT3, DNMT3L domain (ADD).