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. 2022 Aug 18;23(16):9302. doi: 10.3390/ijms23169302

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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ZKSCAN3 induces chromosomal instability by suppressing MAD2L2 expression. (A) CBMN assays for the indicated cells derived from single cells after 40−50 generations. A total of 800 binucleated cells (BNC) were scored for nuclear abnormalities. Data are expressed as mean ± SD. * Statistical significance was determined using one-way ANOVA followed by Duncan’s test (* p < 0.01). (B) FISH analysis of interphase cells using CEP probes. Average 300−500 cells were scored for each cell line; data are expressed as the percentage of aneuploid cells. (C) Fluorescence microscopy images of interphase FISH for indicated cells using probes for chromosomes 7, 12, and 17. Aneuploid cells (arrowhead). Optical magnification, ×600. CBMN, cytokinesis-block micronucleus.