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. Author manuscript; available in PMC: 2022 Aug 25.
Published in final edited form as: Adv Geriatr Med Res. 2022 Jun 30;4(2):e220006. doi: 10.20900/agmr20220006

Figure 1. The effects of aging on SSCs.

Figure 1.

From the bone marrow-derived mouse osteochondral SSCs, the lineage-committed bone, cartilage, and stromal precursor (BCSP) cell gives rise to osteoblasts, chondrocytes, and stromal cells, but not bone marrow adipose. Human perivascular SSCs give rise to bone marrow adipose and under specific circumstances, e.g., fracture—bone, cartilage, and stroma. Aging skews lineage output (indicated by arrows). Surface markers identify skeletal cell types in mice [19,25]. *Chondrocyte generation persists throughout life, however clonal diversity of chondral tissues and generation of articular chondrocytes significantly diminishes with age, while injury-activated SSCs give rise to hypertrophic chondrocytes that generate mostly fibrocartilage [30].