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. 2022 Aug 12;23(16):9014. doi: 10.3390/ijms23169014

Figure 1.

Figure 1

HNSCC cells are sensitive to ferroptosis-inducers. (A–F) The cell viability of CAL33 (A), AMC-HN-8 (B), TU686 (C), CNE-2 (D), S18 (E), and S26 (F) were tested by CCK-8 24 h after treatment with the indicated concentrations of three types of ferroptosis-inducers (RSL3, Erastin, or Sorafenib). (G,H) Cell viability of neural stem cells (NSCs) (G) and N2A cells (H) tested by the same method as the HNSCC cells as the control group. n = 3. The mean ± SEM of three independent experiments is shown. A two-way ANOVA, followed by an uncorrected Fisher’s LSD test, was used for statistical analysis. * p < 0.05; ** p < 0.01; *** p < 0.001; n.s.: not significant. Black triangles: number of experiments with RSL3 treatment; dots: number of experiments with Erastin treatment samples; diamonds: number of experiments treated with Sorafeninb.