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. 2022 Aug 12;23(16):9028. doi: 10.3390/ijms23169028

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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pri-miRNA-Let-7d is over-expressed in IPF fibroblasts, and Let-7d is downregulated in IPF fibroblasts and fibrotic mice lugs. The expression of pri-miRNA-Let-7d is higher in IPF fibroblasts than in control fibroblasts (p = 0.05) (A). The correlation of ADAR1 isoforms does not show significant differences between ADAR1-p110 (B) and ADAR1-p150 (C). The expression of Let-7d is lower in IPF fibroblasts compared to the expression levels of control fibroblasts (** p = 0.0028) (D). Let-7d displayed a negative correlation with ADAR1-p150 (p < 0.0001) (E) and a positive correlation with ADAR1-p110 (p = 0.0014) (F).