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Over-expression of COL3A1 in IPF fibroblasts (black square) vs Normal fibroblasts (black circle) (* p < 0.05) (A), Over-expression of ADAR1p110 wt isoform showed a negative effect on the expression levels of COL3A1 (* < 0.05) and SMAD2 (* p < 0.05) (B,C) in both control and IPF fibroblasts; however, ADARp150 wt showed an increased effect in the expression of COL3A1 in normal and IPF fibroblasts (** p < 0.0001) (B). The expression of SMAD2 did not show changes by ADARp150 (C).
