Table 5.

The binding energy of ligand molecules at the active sites of the p53 protein.

Binding Energy (kcal/mol)	Berberine	Dihydroberberine	Coptisine
Active site 1	−6.7	−6.9	−7.4
Active site 2	−5.8	−5.7	−6.2
Active site 3	−5.8	−5.7	−6.3