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. 2022 Jul 28;12(8):1140. doi: 10.3390/life12081140

Table 2.

Anti-angiogenic and apoptotic of Ole.

In Vivo/In Vitro Type of Cancer/Cell Anti-Angiogenic and Apoptotic of Ole References
In vivo Breast cancer cells
  • -

    Lowering vascular endothelial growth factor (VEGF)

 [9]
MDA-MB-321 in vitro Breast cancer cells
  • -

    Inducing cysteine proteases with aspartate specificity (caspase)-3 cleavage

 [14]
NSCLC H1299 in vitro Lung cancer cells
  • -

    Causing a significant increase in cytochrome c and thus caspase-3

 [57]
MIDA-MB-468 in vitro Breast cancer cells
  • -

    Increasing the expression of many caspases including caspase 1 and 14

 [58]
MDA-MB-231 in vitro Breast cancer cells
  • -

    Increasing caspase 4 expression

 [58]
MIA PaCa-2 in vitro Pancreatic cancer cells
  • -

    Raising the ratio of Bax/Bcl2

[59]
TCAM-2 and SEM-1 in vitro Seminoma Cells
  • -

    Overexpression of BAX

 [30]
NSCLC H1299 in vitro Lung cancer cells
  • -

    Raising the ratio of Bax/Bcl2

[57]
In vitro Breast neuroblastoma
  • -

    Raising the ratio of Bax/Bcl2

[55]
In vitro Hela cervical cancer cells
  • -

    Raising the ratio of Bax/Bcl2

[24]
MCF-7 in vitro Breast cancer cells
  • -

    Affecting the proapoptotic gene tumor protein P53 (p53)

  • -

    Raising Bax/Bcl2 ratio

 [25]
MIA PaCa-2 in vitro Pancreatic cancer cells
  • -

    Dimerizing of c-Jun and c-Fos into API

 [59]
NSCLC H1299 in vitro Lung cancer cells
  • -

    p38/ATF-2 pathway

 [57]
MCF-7 in vitro Breast cancer cells
  • -

    p38/ATF-2 pathway

 [25]
In vitro Hela cervical cancer cell
  • -

    p38/ATF-2 pathway

 [25]
A549 in vitro Lung cancer
  • -

    p38/ATF-2 pathway

 [60]
SH-SY5Y in vitro Neuroblastoma
  • -

    p38/ATF-2 pathway

 [55]
HT-29 in vitro Human colon adenocarcinoma cells
  • -

    Causing down-regulation of hypoxia-inducible factor-alpha (HIF-1α)

 [31]
B16F10 in vivo Melanoma cells
  • -

    Reducing HIF-1α, and adipogenesis

 [61]
In vitro Prostate cancer
  • -

    Inhibiting Akt pathway

 [52]
HepG2 in vitro Hepatocellular
  • -

    Inhibiting Akt pathway

  • -

    Suppressing phosphatidylinositol 3-kinase (PI3K)/Akt/NF-kB and phosphatidylinositol 3-kinase (PI4K)/Akt/mammalian target of rapamycin (mTOR) pathway

 [62]
In vitro HeLa cervical carcinoma cells
  • -

    Producing phosphorylation and activation of the Jnk pathway

 [64]
NSCLC A549 in vitro Non-small-cell lung cancer
  • -

    Increasing the expression of pro-apoptotic Bcl2

 [65]