Table 1.
TIMPs from different metazoans possessing unusual helices in the N-domain and exposure propensity in terms of RSA.
| Species | AA Residues in Helix | Accession | ||
|---|---|---|---|---|
| Primate | Pan troglodytes | TIMP-4 | FEKV EBEE |
XP_516284.1 |
| TIMP-3 | KMPKV IEIBB |
XP_515097.2 | ||
| Rodent | Rattus norvegicus | TIMP-1 | FDA EEI |
NP_446271.1 |
| TIMP-4 | FEKAK IBEEE |
NP_001102863.1 | ||
| Bird | Columba livia | TIMP-4 | FEKL IBEE |
EMC77392.1 |
| Turtle | Chelonia mydas | TIMP-4 | FEKV EBEE |
XP_007056544.1 |
| Sea urchin | Strongylocentrotus purpuratus | TIMP-3 | EKLKH EEBEE |
XP_781027.1 |
| Insect | Stegodyphus. mimosarum | TIMP | EKARRA EEEBEE |
KFM62985.1 |
| Molluscs | Crassostrea gigas | TIMP-1 | SLLGS EEBIE |
AAT73610.1 |
| TIMP-2 | KGSSLL IBBEEI |
NP_001292265.1 | ||
| Tegillarca granosa | TIMP | PAFEEL EEEBEE |
AFB81539.1 | |
| Cnidarian | Hydra magnipapillata | TIMP3a | NPSYRFNLQQIH EIIIEEEIEEBB |
449680372 |
| TIMP3b | YQFNL EEIIEE |
221128951 | ||
| TIMPa | NLQQIH EBEEBI |
449683625 |
TIMPs and corresponding RSAs are according to [10]. Amino-acid residues structuring the helices are shown, while the corresponding RSA behaviour is shown in bold: exposed residue (E), intermediate residue (I) and buried residue (B).