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. 2022 Aug 18;20(8):527. doi: 10.3390/md20080527

Figure 6.

Figure 6

Application of phloroglucinol in the form of nanoparticles for treating infectious and non-infectious diseases. (A) The cytotoxicity action of phloroglucinol-engineered AgNPs towards MCF-7 breast cancer cell lines. (a) SEM image of AgNPs and (b) TEM image of AgNPs. Reproduced with permission from reference [137]. (B) Synthesis of the phloroglucinol-conjugated gold nanoparticles, which exhibit therapeutic potential towards cancer cells. The action mechanism involved apoptosis of cancer cells by promoting mitochondrial transmembrane permeation, as evident by fluorescence staining and gene expression studies. Reprinted with permission from reference [138], (C) Encapsulation of phloroglucinol into the chitosan nanoparticles. The PG-CSNPs exhibit antibiofilm properties towards single- and mixed-species biofilms of C. albicans-S. aureus/S. mutans/K. penumoniae. Reprinted with permission from reference [139], and (D) Synthesis of metal (AuNPs) and metal oxide (ZnONPs) nanoparticles using phloroglucinol. The synthesized PG-AuNPs and PG-ZnONPs showed antibiofilm and antivirulence properties towards P. aeruginosa. Reproduced with permission from reference [140]. Copyright 2021 by the authors and licensee MDPI, Basel, Switzerland.