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A model for the synthesis of acyl-HSLs by the LuxI protein family. This model is based primarily on information about LuxI (15) and the LuxI homolog, RhlI (11). SAM binds to the enzyme, followed by acyl-ACP. An amide bond is formed between SAM and the acyl group, and holo-ACP is released. The acyl-SAM intermediate cyclizes, releasing the acyl-HSL and methylthioadenosine (MTA).
