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. 2022 Aug 11;8(8):845. doi: 10.3390/jof8080845

Figure 1.

Figure 1

Maximum likelihood (ML) phylogram of the concatenated TEF1-α and RPB2 sequences for the 30 Malaysian FSSC isolates and 37 publicly available sequences of globally distributed FSSC isolates. DNA sequences of two close relatives (F. cicatricum and F. staphyleae) were used as the outgroup. Isolates characterised in this study are highlighted in bold font. The source of individual isolates (E = environmental, H = hospital, P = plant) is shown in the column to the right of the strain identifier. The voriconazole resistant (MIC > 32 mg/L) isolates with the 23 bp CYP51A promoter deletion and the voriconazole susceptible (MIC ≤ 12 mg/L) isolates are indicated with R and S, respectively. The voriconazole susceptibilities of isolates marked with a question mark (?) were not determined. Technical issues prevented the confirmation of the 23 bp CYP51A promoter deletion in the voriconazole resistant F. falciforme (Ff0020) and F. striatum (Fstr541) isolates (marked with asterisks; *). The roots, with 100% bootstrap support, of the three major FSSC clades (clades 1, 2 and 3) are in bold. Numbers at internodes represent the percentage maximum parsimony (MP) and maximum likelihood (ML) bootstrap support (MP-BS/ML-BS) of 1000 replicates; a single value means that both values were identical. The scale bar indicates the number of nucleotide substitutions per position.