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. 2022 Aug 5;12(8):1284. doi: 10.3390/jpm12081284

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of adipose-derived stem cell conditioned medium (ADSC CM) on the transmigration (A), invasion (B), and cell survival (C) of MCF-10A cells. MCF-10A cells were cultured as a mono- or co-culture with fibroblasts; irradiated with 0, 2, or 5 Gy; and treated with either ADSC CM or control CM. Data from the ADSC CM treatment group were normalized to the corresponding group treated with control CM (control = 1). (A–C) Columns show the ratio of transmigrated cells (A), invaded cells (B), and the survival fraction (C) compared to the control group (y-axis) in mono- and co-cultured cells in varying irradiation doses treated with ADSC CM or control CM (x-axis). n = 3 replicate experiments, and values are presented as mean ± SD. * p < 0.05, and the ADSC CM was compared to the control CM (Mann–Whitney U-test).