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. 2022 Aug 5;12(8):1284. doi: 10.3390/jpm12081284

Figure 2.

Figure 2

Effect of co-cultured fibroblasts on the transmigration (A), invasion (B), and cell survival (C) of MCF-10A cells compared to monocultured MCF-10A cells. MCF-10A cells were cultured as mono- or co-culture with fibroblasts; irradiated with 0, 2, or 5 Gy; and treated either with adipose-derived stem cell conditioned medium (ADSC CM) or control CM. Data from the co-culture group were normalized to the corresponding monoculture group (control = 1). (A–C) Columns show the ratio of transmigrated cells (A), invaded cells (B), and the survival fraction (C) compared to the control group (y-axis) in mono- and co-cultured cells in varying irradiation doses and treated with ADSC CM or control CM (x-axis). n = 3 replicate experiments, and values are presented as mean ± SD. * p < 0.05, and the co-culture was compared to the monoculture (Mann-Whitney U-Test).