Table 2.

Summary of key features of oral manifestations in selected diseases.

Disease	Type	Immune Factors	Risk Factors	Symptoms
MMP	Autoimmune dermatoses disease	Linear deposition of IgG, IgA, C3, rarely IgG Target antigens in the basement membrane region of the epithelium: BP230, BP180, laminin 5, laminin 6, type VII collagen and β4	Age > 50 years, female sex	Subepidermal bullous lesions
PV	Autoimmune disease	Autoantibodies react to Dsg 1 and 3	-	Ulceration of the oral and esophageal mucosa, followed by skin involvement
LABD	Subepidermal vesiculobullous disease	Deposition of IgA rather than IgG in the basement membrane	Genetic factors, medication (vancomycin) and antibiotic use (cephalosporins, penicillins)	Oral lesions clinically identical to MMPs
EBA	Autoimmune blistering disease	IgG autoantibodies directed against type VII collagen	-	Blisters and blisters on the skin and erosions on the mucous membranes
HIES	Multisystem disorder	-	STAT3 mutations	Facial asymmetry, fleshy nose tip, deep-set eyes, prominent forehead, triad of eczema, recurrent skin and lung infections, high serum IgE levels, preserved primary dentition, oral mucosal and gingival lesions, oral candidiasis

IgG: immunoglobulin G; IgA: immunoglobulin A; IgE: immunoglobulin E; C3: complement component 3; MMP: mucous membrane pemphigoid; PV: pemphigus vulgaris; LABD: linear IgA bullous dermatosis; EBA: Epidermolysis Bullosa Aquisita; HIES: Hyper-IgE syndrome; STAT3: Signal transducer and activator of transcription 3.