Table 2.
Effects of CD24 signaling different subtypes of immune cells.
| Immune Cell Subype | Effect | Proposed Mechanism | Outcome |
|---|---|---|---|
| T cells | Regulation of proliferation | Inhibition of rapid T cell proliferation in lymphopenic hosts | Inhibition |
| T cells | Downregulation of Th1, upregulation of Treg cells | CD24+ Breg cells | Inhibition |
| T cells | Promotion of the differentiation of memory/effector T cells | Costimulatory signal for naive CD8+ T cells | Activation |
| NK cells | Reduced NK cell cytotoxicity | Siglec-10-mediated | Inhibition |
| Macrophages | Inhibition of phagocytosis | Siglec-10-mediated | Inhibition |
| Monocytes/neutrophils | Hematogenous spread | P-selectin-mediated cell adhesion to activated endothelial cells or platelets | Activation |
| Dendritic cells | Suppression of immune response to tissue damage | Inhibition of TLR-mediated inflammation via Siglec-10 interaction | Inhibition |