Table 2.
Association of genetically predicted circulating TIMP3 levels with CAD and MI risk in complementary analyses.
| Data Source | Outcome | SNPs, n | Method | OR | 95% CI | p−Value |
|---|---|---|---|---|---|---|
| CARDIoGRAMplusC4D | CAD | 7 | IVW (random−effects) | 0.97 | 0.96, 0.97 | 7.26 × 10−38 |
| 7 | Weighted median | 0.97 | 0.95, 0.99 | 8.30 × 10−3 | ||
| 7 | MR−Egger | 0.97 | 0.94, 1.01 | 0.204 | ||
| 7 | MR−PRESSO * | 0.97 | 0.96, 0.97 | 1.36 × 10−5 | ||
| CARDIoGRAMplusC4D | MI | 7 | IVW (random−effects) | 0.96 | 0.95, 0.97 | 4.49 × 10−13 |
| 7 | Weighted median | 0.96 | 0.94, 0.99 | 7.58 × 10−3 | ||
| 7 | MR−Egger | 0.97 | 0.93, 1.01 | 0.208 | ||
| 7 | MR−PRESSO * | 0.96 | 0.95, 0.97 | 3.53 × 10−4 | ||
| FinnGen | CAD | 7 | IVW (random−effects) | 0.98 | 0.96, 1.01 | 0.226 |
| 7 | Weighted median | 0.97 | 0.94, 1.00 | 0.027 | ||
| 7 | MR−Egger | 0.96 | 0.91, 1.02 | 0.252 | ||
| 7 | MR−PRESSO * | 0.98 | 0.96, 1.01 | 0.272 | ||
| FinnGen | MI | 7 | IVW (random−effects) | 0.99 | 0.96, 1.02 | 0.469 |
| 7 | Weighted median | 0.98 | 0.94, 1.01 | 0.166 | ||
| 7 | MR−Egger | 0.98 | 0.91, 1.04 | 0.503 | ||
| 7 | MR−PRESSO * | 0.99 | 0.96, 1.02 | 0.497 |
CARDIoGRAMplusC4D, Coronary Artery Disease Genome−Wide Replication and Meta−analysis plus the Coronary Artery Disease Genetics; CAD, coronary artery disease; MI, myocardial infarction; SNPs, single−nucleotide polymorphisms; IVW, inverse−variance weighted; MR−Egger, Mendelian randomization−Egger; MR−PRESSO, MR−pleiotropy residual sum and outlier; OR, odds ratio; CI, confidence interval. * No outliers detected.