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. 2022 Aug 18;9(8):277. doi: 10.3390/jcdd9080277

Table 3.

Evaluation of heterogeneity and directional pleiotropy using different methods.

Data Source Outcome Heterogeneity Pleiotropy
I2 (%) Cochran’s Q p MR−Egger Intercept p MR−PRESSO Global Test p
CARDIoGRAMplusC4D CAD 0 0.925 0.722 0.997
MI 0 0.997 0.761 0.946
FinnGen CAD 18 0.315 0.432 0.319
MI 4 0.395 0.660 0.367

CARDIoGRAMplusC4D, Coronary Artery Disease Genome−Wide Replication and Meta−analysis plus the Coronary Artery Disease Genetics; CAD, coronary artery disease; MI, myocardial infarction; MR−Egger, Mendelian randomization−Egger; MR−PRESSO, MR−pleiotropy residual sum and outlier.