Table 1.
Organ weight changes in HFD-induced metabolic alteration.
| NFD | HFD | MET | KO400 | KO200 | KO100 | |
|---|---|---|---|---|---|---|
| Liver | 1.29 ± 0.07 (4.3 ± 0.2) |
1.90 ± 0.10 ‡ (4.5 ± 0.4) |
1.63 ± 0.11 ‡,** (4.5 ± 0.3) |
1.44 ± 0.10 ‡,** (4.3 ± 0.4) |
1.61 ± 0.10 ‡,** (4.6 ± 0.4) |
1.71 ± 0.06 ‡,** (4.6 ± 0.3) |
| Pancreas | 0.25 ± 0.04 (0.8 ± 0.1) |
0.24 ± 0.03 (0.6 ± 0.1 ‡) |
0.26 ± 0.02 (0.7 ± 0.1 **) |
0.26 ± 0.02 (0.8 ± 0.1 **) |
0.26 ± 0.01 (0.7 ± 0.0 **) |
0.25 ± 0.02 (0.7 ± 0.1 ‡,*) |
| Kidney | 0.21 ± 0.01 (0.7 ± 0.0) |
0.30 ± 0.01 ‡ (0.7 ± 0.1) |
0.26 ± 0.01 ‡,** (0.7 ± 0.0) |
0.24 ± 0.01 ‡,** (0.7 ± 0.0) |
0.25 ± 0.01 ‡,** (0.7 ± 0.0) |
0.27 ± 0.01 ‡,** (0.7 ± 0.0) |
| A. fat | 0.07 ± 0.03 (0.2 ± 0.1) |
0.44 ± 0.08 ‡ (1.1 ± 0.2 ‡) |
0.24 ± 0.05 ‡,** (0.7 ± 0.2 ‡,**) |
0.18 ± 0.05 ‡,** (0.5 ± 0.2 ‡,**) |
0.24 ± 0.05 ‡,** (0.7 ± 0.2 ‡,**) |
0.30 ± 0.03 ‡,** (0.8 ± 0.1 ‡,**) |
| O. fat | 0.08 ± 0.03 (0.3 ± 0.1) |
0.45 ± 0.11 ‡ (1.1 ± 0.3 ‡) |
0.23 ± 0.05 ‡,** (0.6 ± 0.1 ‡,**) |
0.15 ± 0.03 ‡,** (0.4 ± 0.1 †,**) |
0.22 ± 0.03 ‡,** (0.6 ± 0.1 ‡,**) |
0.27 ± 0.03 ‡,** (0.7 ± 0.1 ‡,*) |
Absolute organ weights (g) of the liver, pancreas, kidney, abdominal (A.), and periovarian (O.) fat masses were measured, and the relative organ weights to the body weight (%) are indicated in parenthesis. Values are expressed as the mean ± standard deviation (SD). ‡ p < 0.01 and † p < 0.05 versus the NFD. ** p < 0.01 and * p < 0.05 versus the HFD control (HFD).