Table 3.
Cluster Analysis in high-risks patients.
| Variable | Cluster 1 n = 396 |
Cluster 2 n = 47 |
p |
|---|---|---|---|
| Origin (Urban) | 299 (74.9) | 36 (76.6) | 0.8 |
| Age (years) | 61 (21) | 77 (16) | 0.00 |
| Sex (women) | 185 (46.4) | 27 (57.4) | 0.15 |
| SARC-F (>4) | 72 (16) | 37 (78.7) | 0.00 |
| HBP | 275 (68.9) | 42 (89.4) | 0.003 |
| T2DM | 169 (42.4) | 25 (53.2) | 0.15 |
| Dyslipidemia | 265 (66.4) | 34 (72.3) | 0.41 |
| Hyperuricemia | 75 (18) | 19 (40.4) | 0.0006 |
| HF | 57 (14.3) | 27 (57.4) | 0.0001 |
| CAD | 27 (6.7) | 10 (21.3) | 0.0006 |
| Stroke | 22 (5.5) | 12 (25.5) | 0.00 |
| GERD | 53 (13.3) | 10 (21.3) | 0.13 |
| COPD/Asthma | 43 (10.8) | 5 (10.6) | 0.97 |
| Cancer | 8 (2) | 5 (10.6) | 0.0009 |
| Arthrosis | 109 (27.3) | 29 (61.7) | 0.0001 |
| Depression | 78 (19.5) | 17 (36.2) | 0.008 |
| Disability | |||
| Moderate | 77 (19.3) | 12 (25.5) | 0.000 |
| Severe | 12 (3.01) | 30 (63.8) | 0.000 |
| Comorbidities Charlson Index | |||
| Mild (0–1) | 316 (79.2) | 4 (8.5) | 0.000 |
| Moderate (2) | 64 (16) | 18 (38.3) | 0.000 |
| Severe (≥3) | 19 (4.8) | 25 (53.2) | 0.000 |
| BMI (kg/m2) | 34.7 (6.6) | 34.5 (8.89) | 0.46 |
| WC (cm) | 112 (13.9) | 116.3 (15.7) | 0.02 |
| FPG (mg/dL) | 104 (32) | 106.5 (37) | 0.79 |
| eGFR (mil/min/1.73 m2) | 86.1 (30.4) | 52.1 (42.4) | 0.000 |
| Uric acid (mg/dL) | 5.8 (2.2) | 7.4 (3.3) | 0.00 |
| hsCRP (mg/dL) | 2.1 (4.5) | 5.8 (4.1) | 0.008 |
| HDL-Chol (mg/dL) | 46 (15) | 48 (16) | 0.63 |
| LDL-Chol (mg/dL) | 97 (51) | 93 (67.5) | 0.9 |
| Triglycerides (mg/dL) | 136 (87) | 134.3 (72) | 0.95 |
| HbA1c (%) | 5.9 (1.2) | 6.3 (2) | 0.05 |
| AST (U/L) | 23 (17) | 15.5 (12.2) | 0.001 |
| ALT (U/L) | 21 (12) | 18 (7.5) | 0.01 |
| GGT (U/L) | 31 (31) | 35 (36.5) | 0.11 |
| ALP (U/L) | 79 (35) | 79.5 (37.5) | 0.3 |
| Hemoglobin (g/dL) | 14.1 (2.3) | 13 (2.2) | 0.000 |
| Leukocytes (×109/L) | 7.4 (2.7) | 8.3 (3.2) | 0.007 |
| Lymphocytes (×109/L) | 2.2 (1) | 1.9 (1.7) | 0.33 |
| Platelets (×109/L) | 237 (95) | 257 (115) | 0.97 |
| Albumin (mg/dL) | 4.3 (0.5) | 3.9 (0.7) | 0.000 |
| UACR (mg/g) | 9 (17.8) | 15 (38.2) | 0.17 |
| TyG index | 4.1 (0.3) | 4.1 (0.3) | 0.91 |
| C-reactive Protein/Albumin ratio (CAR) | 0.5 (1.1) | 1.3 (3.4) | 0.01 |
| Lymphocyte to CRP ratio (LCR) | 0.925 (1.86) | 0.52 (0.9) | 0.002 |
Legend: ALP: alkaline phosphatase; ALT: Alanine transaminase; AST: Aspartate transaminase; BMI: body mass index; CAD: coronary artery disease; COPD: chronic obstructive pulmonary disease; eGFR: estimated glomerular filtration rate; FPG: fasting plasma glucose; FPG: Fasting plasma glucose; GERD: gastroesophageal reflux disease; GGT: Gamma-glutamyl transferase; HBP: high blood pressure; HbA1c: glycated hemoglobin; HDL: high density lipoprotein; hsCRP: high-sensitivity C-reactive protein; HF: heart failure; LDL: low density lipoprotein; T2DM: type 2 diabetes mellitus; UACR: Urinary albumin-to-creatinine ratio; SARC-F: Strength, Assistance in walking, Rise from a chair, Climb stairs, and Falls questionnaire; WC: waist circumference.