Extended Data Fig. 7 |. Scavenger receptor deletion facilitates post-MI ventricular.

a, Experimental outline for C57BL/6 controls, Cd36^−/− and Mertk^−/− mice, all undergoing STORM. b, ECG tracing from a Cd36^−/− mouse experiencing sustained ventricular tachycardia (VT) transforming into ventricular fibrillation (Vfib) and leading to sudden cardiac death shortly after MI induction. c, VT incidence and Vfib incidence (mouse numbers in plots) from telemetric ECG recordings in ambulatory C57BL/6 STORM mice (n = 7 mice) and Cd36^−/− STORM mice (n = 8). Two-sided Fisher’s exact tests were used. d, VT incidence and Vfib incidence (mouse numbers in plots) from telemetric ECG recordings in ambulatory C57BL/6 STORM mice (n = 9 mice) and Mertk^−/− STORM mice (n = 9). Two-sided Fisher’s exact tests were used. e, Experimental outline for bone marrow transplantation using wild type Cd36^+/+ or Cd36^−/− donor mice. Lethally irradiated recipients were Cd36^+/+ mice that subsequently underwent STORM. f, VT incidence and Vfib incidence (mouse numbers in plots) from telemetric ECG recordings in ambulatory Cd36^+/+ control bone marrow chimeras (n = 8 mice) and Cd36^−/− bone marrow chimeras (n = 9) after STORM procedure. Two-sided Fisher’s exact tests were used. g, Flow plots demonstrating Cre activity in resident cardiac macrophages of Cx₃cr1^CreERT2/Ai9 mice after consuming tamoxifen diet for 10 days. Unpaired t-test was used. h, Experimental outline. Cx₃cr1^CreER;Mertk^fl/fl mice and Cx₃cr1^CreER control mice were fed with tamoxifen (tamox)-containing diet for 10 days. i, VT incidence and Vfib incidence (mouse numbers in plots) from telemetric ECG recordings in ambulatory Cx₃cr1^CreER controls and Cx₃cr1^CreER;Mertk^fl/fl mice after STORM procedure. Two-sided Fisher’s exact tests were used. Data are mean ± SEM.