Skip to main content
. Author manuscript; available in PMC: 2022 Aug 25.
Published in final edited form as: Nat Cardiovasc Res. 2022 Jul 11;1(7):649–664. doi: 10.1038/s44161-022-00094-w

Fig. 4 |. Macrophages protect against ventricular arrhythmia.

Fig. 4 |

a, Experimental outline for macrophage depletion with Csf1R inhibitor in STORM mice. b, Flow plots and quantification of cardiac monocytes and macrophages (Macs) in STORM control mice (n = 6) and after macrophage depletion by Csf1Ri (n = 7). A two-sided unpaired t-test (monocytes) and a two-sided Mann–Whitney test (macrophages) were used for statistical analysis. c, ECG recordings from STORM mice with and without macrophage depletion after MI. d, VT burden (STORM control mice, n = 11; STORM Csf1Ri, n = 15) and Vfib burden (STORM control mice, n = 6; STORM Csf1R, n = 5) within 24 hours after MI. Two-sided Mann–Whitney tests were used for statistical analysis. e, Experimental outline. f, Flow cytometry for cardiac monocytes and macrophages (Macs) in wild-type STORM control mice (n = 8) and Ccr2−/− STORM mice (n = 9). A two-sided unpaired t-test (monocytes) and a two-sided Mann–Whitney test (macrophages) were used for statistical analysis. g, ECG recordings from wild-type STORM control and Ccr2−/− STORM mice. h, VT burden (wild-type STORM control, n = 10 mice; Ccr2−/− STORM, n = 19) and Vfib burden (wild-type STORM control, n = 8; Ccr2−/− STORM, n = 14) after MI. Two-sided Mann–Whitney tests were used for statistical analysis. Data are mean ± s.e.m.