TABLE 1.
Comparison of core gene clusters involved in secondary metabolites biosynthesis in strains CX03, CX06, MA97-1, C3, 55 and 76.
| Antibiotic name | Type | Core gene clusters | Size | Position | CX03 | CX06 | C3 | M497-1 | 55 | 76 |
| Xanthomonadin I | Arylpolyene | fabB | 41,200 | 386,889–428,088 | JHW38_18245–JHW38_18410 | JHW41_01600–JHW41_01760 | GLE_RS21925–GLE_RS22085 | LEN_RS02150–LEN_RS02315 | LC55x_RS22660-LC55x_RS22790 | NA |
| Le-pyrrolopyrazines | NRPS; RiPP-like | K09930 | 58,001 | 2,518,673–2,576,673 | JHW38_05710–JHW38_05915 | JHW41_10560–JHW41_10760 | GLE_RS12970–GLE_RS13160 | LEN_RS10150–LEN_RS10345 | NA | NA |
| Lankacidin C | Redox-cofactor | pqqCDE | 22,191 | 1,625,895–1,648,201 | JHW38_09520–JHW38_09630 | JHW41_07015–JHW41_07120 | GLE_RS16545–GLE_RS16650 | NA | LC55x_3908–LC55x_3932 | LA76x_RS17710–LA76x_RS17810 |
| Heat-stable antifungal factor | T1PKS; NRPS | NA | 49,486 | 2,263,501–2,312,986 | NA | JHW41_09425–JHW41_09585 | GLE_RS14120–GLE_RS14275 | NA | LC55x_1990–LC55x_2023 | NA |
| WAP-8294A2 | NRPS | mbtH, nocI | 89,028 | 1,728,431–1,817,458 | NA | JHW41_07340–JHW41_07515 | GLE_RS16150–GLE_RS16310 | NA | NA | NA |
| Chlorotonil A | NRPS | pksJLN, fabB | 47,083 | 3,892,265–3,939,347 | NA | JHW41_12850–JHW41_13055 | GLE_RS10810–GLE_RS11030 | LEN_RS12320–LEN_RS12520 | NA | NA |
| BE-43547A1 | NRPS, lanthipeptide-class-ii | gtrB, csbB, fadD | 67,920 | 5,253,420–5,321,339 | NA | JHW41_21620–JHW41_21865 | GLE_RS02295–GLE_RS02540 | NA | NA | NA |
| Thailanstatin A | NRPS, PKS-like, T3PKS, transAT-PKS | ppsB, pksDFGL, fabD | 123,854 | 540,483–664,336 | JHW38_02545–JHW38_02810 | NA | NA | NA | NA | NA |
| Unknown | RiPP-like | K09930 | 9,371 | 2,167,353–2,176,723 | JHW38_07405–JHW38_07465 | JHW41_09025–JHW41_09080 | GLE_RS14610–GLE_RS14670 | LEN_RS08690–LEN_RS08745 | LC55x_1902–LC55x_1914 | LA76x_RS08985–LA76x_RS09040 |
| Unknown | NRPS | entF | 41,663 | 4,398,433–4,440,095 | JHW38_18540–JHW38_18725 | JHW41_01905–JHW41_02080 | GLE_RS21600–GLE_RS21775 | LEN_RS22320–LEN_RS22485 | NA | LA76x_RS01375–LA76x_RS01565 |
| Unknown | NRPS | tssF | 81,718 | 1,060,275–1,141,992 | JHW38_04265–JHW38_04500 | JHW41_12565–JHW41_12740 | GLE_RS11135–GLE_RS11310 | NA | NA | LA76x_RS12285–LA76x_RS12440 |
| Unknown | Lanthipeptide-class-ii | ydhP | 22,877 | 4,548,972–4,571,848 | JHW38_19190–JHW38_19295 | JHW38_19190–JHW38_19295 | GLE_RS10630–GLE_RS10710 | NA | NA | LA76x_RS12285–LA76x_RS12440 |
| Unknown | NRPS | entF, entE, dhbE, vibe, mxcE | 41,926 | 966,828–1,008,753 | JHW38_03880–JHW38_04055 | NA | NA | LEN_RS11870–LEN_RS11980 | NA | LA76x_RS11825–LA76x_RS12000 |
| Unknown | Lanthipeptide-class-iii | lanKC | 22,730 | 3,031,820–3,054,549 | JHW38_12680–JHW38_12755 | NA | NA | NA | LC55x_RS10165–LC55x_RS10235 | NA |
| Unknown | NRPS, T1PKS | fadEG, ampC | 59,610 | 5,194,324–5,253,933 | JHW38_21965–JHW38_22130 | NA | NA | LEN_RS18810–LEN_RS18960 | NA | NA |
| Unknown | NRPS, transAT-PKS | fabD, pksL | 82,610 | 3,582,829–3,658,580 | NA | JHW41_14645–JHW41_14785 | GLE_RS09115–GLE_RS25730 | NA | NA | NA |
| Unknown | Lanthipeptide-class-ii | yojI | 21,693 | 973,830–995,522 | NA | JHW41_04130–JHW41_04225 | GLE_RS19595–GLE_RS19685 | NA | NA | NA |
| Unknown | Lanthipeptide-class-ii | fimA | 22,877 | 5,359,830–5,382,706 | NA | JHW41_22055–JHW41_22145 | GLE_RS02010–GLE_RS02095 | LEN_RS21820–LEN_RS21890 | LC55x_RS21600–LC55x_RS21695 | NA |
| Unknown | NRPS | K0066, pchF | 47,083 | 3,892,265–3,939,347 | NA | JHW41_15810–JHW41_15980 | GLE_RS08020–GLE_RS08165 | NA | NA | LA76x_RS14890–LA76x_RS15050 |
| Unknown | NRPS | queCE | 43,547 | 1,365,062–1,408,608 | NA | JHW41_05845–JHW41_06035 | GLE_RS17615–GLE_RS17765 | NA | NA | NA |
NA, not available.