Table 1.

Inclusion and exclusion criteria for the study enrollment.

Inclusion criteria	Exclusion criteria
• Participants who voluntarily participate in this study and sign an informed consent form.	• History of systemic or nasal use of antibotics, antifungal, hormones, and other medications affecting the microecology of the flora within 3 months.
• Age: 18 to 65 yr, gender is not limited.	• History of systemic or nasal use of probiotics/probiotic products (including medications, yogurt, beverages) within 3 months.
• No nasal diseases such as nasal tumor, congenital malformation, and structural abnormality.	• Obviously mental disorders.
• No organic digestive system diseases such as peptic ulcer, inflammatory bowel diseases, gastrointestinal tumor.	• Long history of smoking.
• No serious primary diseases in cardiovascular, digestive, urinary, and hematopoietic system.	• Pregnancy and lactation.
• Factory workers with fixed working time ≥ 8 hr/d and continuous working years ≥ 3 yr.