Table 3.
Risk of early pregnancy loss by univariate and multivariate logistic regression analyses.
| Variables | Univariable | Multivariable | ||
|---|---|---|---|---|
| OR (95% CI) | P | OR (95% CI) | P | |
| Maternal age (y) | ||||
| <35 | Reference | Reference | ||
| ≥35, <40 | 1.25 (0.78, 2.02) | .3565 | 0.80 (0.40, 1.58) | .5215 |
| ≥40 | 4.33 (2.39, 7.87) | <.001 | 2.33 (0.90, 6.04) | .0816 |
| Paternal age (y) | ||||
| <35 | Reference | Reference | ||
| ≥35, <40 | 1.45 (0.93, 2.28) | .1045 | 1.32 (0.74, 2.34) | .3503 |
| ≥40 | 2.46 (1.47, 4.14) | <.001 | 1.33 (0.57, 3.09) | .5057 |
| Type of infertility | ||||
| Primary | Reference | Reference | ||
| Secondary | 1.72 (1.19, 2.49) | .0041 | 1.44 (0.91, 2.28) | .1158 |
| Total AFC | ||||
| <10 | 2.23 (1.38, 3.62) | .0011 | 2.97 (1.38, 6.38) | .0054 |
| ≥10, <15 | Reference | |||
| ≥15 | 1.22 (0.76, 1.95) | .4173 | 1.10 (0.64, 1.92) | .7242 |
| Total Gn dose (IU) | ||||
| <3150.73 | Reference | Reference | ||
| ≥3150.73 | 1.60 (1.10, 2.33) | .0147 | 1.34 (0.67, 2.69) | .4062 |
| E2/P | ||||
| <1.1 | Reference | Reference | ||
| ≥1.1 | 0.45 (0.26, 0.78) | .0043 | 0.51 (0.28, 0.91) | .0225 |
| Number of metaphase-2 oocytes | ||||
| <7 | Reference | Reference | ||
| ≥7 | 0.61 (0.40, 0.94) | .0252 | 0.82 (0.45, 1.48) | .5016 |
| Serum hCG level (IU/L) | ||||
| <591.7 | Reference | Reference | ||
| ≥591.7 | 0.19 (0.12, 0.28) | <.001 | 0.44 (0.21, 0.92) | .0304 |
AFC = total antral follicle count, CI = confidence interval, COH = controlled ovarian hyperstimulation, Gn = gonadotropin, hCG = human chorionic gonadotropin, IVF/ICSI = in vitro fertilization/intracytoplasmic sperm injection, OR = odds ratio.