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The alpha and beta diversity analysis of gut microbiota in CD patients during ADA therapy. Alpha diversity indices as estimated using the number of observed OTU (A), Shannon index (B), Simpson index (C), Chao index (D), ACE index (E), coverage (F), and rarefaction curves (G); beta diversity of gut microbiota calculated via PCoA across all pre- and post-ADA samples using Bray–Curtis distance (H); ns, not significant.
