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. 2022 Aug 11;13:913720. doi: 10.3389/fphar.2022.913720

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Copyright © 2022 Chen, Lu, Kang, Feng, Li, Sun, Liu, Wu and Fang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microbial functional alterations in ADA response. The relative abundances of functional pathways (A) and bacterial genes (B) were compared between the nonresponsive adalimumab and responsive adalimumab samples. Differentially abundant pathways are highlighted in blue and red; p values were computed using a two-sided blocked Wilcoxon rank-sum test and the exact p values <0.05 are presented beside the barplots. Generalized fold change (see the Materials and Methods section) is indicated by color gradients. The \generalized fold change >0: enriched in the former; generalized fold change <0: enriched in the latter.