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. 2022 Aug 10;50(15):8898–8918. doi: 10.1093/nar/gkac644

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© The Author(s) 2022. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 3. — Structural overview of select interactions between IN and nucleic acids within the MMTV STC. (A, B) IN–vDNA interactions either (A) proximal to or (B) distal from the MMTV IN active site. (C, D) IN–tDNA contacts, including (C) base-specific interactions (Pro125) and/or sidechain insertions into tDNA major/minor grooves (Tyr149) and (D) backbone interactions. In all panels, nucleotides are labeled in bold, amino acid side chains are colored by their respective protein chains, the non-transferred vDNA strand is in orange, the transferred vDNA strand is in magenta, tDNA is in black, and catalytic triad DDE residues Asp65, Asp122 and Glu158 are labeled in red. Insets show the regions of the STC enlarged (red boxes) within separate panels.