Fig. 2.

Receptor editing using crispr-cas9.HIV enters the cell by binding CD4 receptor and CXCR4 or CCR5 co-receptors. Crispr-Cas9 targeted against CXCR4 or CCR5 gene creates cells that are devoid of these co-receptors. HIV is unable to attack cells in the absence of co-receptor CXCR4 or CCR5, thereby providing resistance to the cell from HIV infection