Table 1.
Overview of candidate SNPs retrieved from previous studies and included in our replication analysis.
| Gene | Subgroup | Rs-id | SIGN. LITERATURE (p value)ref. | NOT SIGN. LITERATURE (p value)ref. | Powera (α = 0.05) |
|---|---|---|---|---|---|
| ABCA3 | Extracellular processes | rs13332514 | (0.002)52 | — | 1 |
| ACE | rs8066114 | (5.0 × 10−3)63 | (0.98)8 | ||
| MMP16 | rs2664352 | (0.013)64 | (0.185)59 | ||
| rs2664349 | (0.047)64 | — | |||
| VEGF | rs699947 | (0.0138)65 | (0.29)8 | ||
| rs833061 | (0.013)66 | (0.3)8 | |||
| SFTPB | rs2077079 | (0.018)67 | |||
| SFTPD | rs2243639 | (0.005)67 | — | ||
| rs721917 | (0.014)67; (0.03)63 | (0.81)8 | |||
| NFE2L2 | rs6721961 | (0.0007)68 | — | 1 | |
| NQO1 | rs1800566 | (0.023)68 | — | 0.7 | |
| MBL2 | Recognition | rs1800450 | (0.001)69; (0.0068)7 | (0.43)70 | 1 |
| rs11003125 | (0.02)70 | (0.57)8 | |||
| rs7096206 | (0.0372)7 | — | 1 | ||
| TIRAP | rs8177374 | (0.04)71 | (0.77)8 | 1 | |
| TLR4 | rs11536898 | (0.01)72 | — | 0.91 | |
| TLR5 | rs5744168 | (0.03)71 | (0.19)8 | 0.96 | |
| TLR6 | rs5743827 | (0.03)72 | — | 0.97 | |
| TLR10 | rs11096955 | (0.0149)65 | (0.21)8 | ||
| PSMF1 | rs2235587 | (0.00104)13,b | — | 0.42 | |
| CRP | rs11265269 | (5.3 × 10−5)12,b | — | 0.97 | |
| rs3093059 | (0.0065)12,b | — | 0.90 | ||
| CARD17/CASP1P1 | Cytokines | rs11226613 | (5 × 10−6)8,b | — | 0.44 |
| IFG | rs2430561 | (0.049)73 | (0.7)8 | ||
| IL18 | rs360721 | (<0.001)74 | — | 1 | |
| IL18R1 | rs3771171 | (6.33 × 10−6)75 | — | 1 | |
| IL18RAP | rs3771150 | (8.31 × 10−7)75 | — | 1 | |
| MIF | rs755622 | (0.04)76 | (0.98)8 | 1 | |
| TNF | rs1799724 | (0.0085)65 | (0.17);77 (0.71)8 | ||
| rs361525 | (0.026)78 | (0.132)79 | |||
| FGFR-4 | Cellular processes | rs1966265 | (0.023)59 | — | |
| GSTP-1 | rs1695 | (0.05)80 | — | 1 | |
| IPO13 | rs4448553 | (0.04)81 | — | 1 | |
| NFKBIA | rs2233409 | (0.024)82 | — | ||
| rs2233406 | (0.026)82 | — | |||
| VDR | rs2228570 | (0.004)83 | — | 0.98 | |
| rs731236 | (0.04)83 | — | 1 | ||
| WDR45L | rs8082435 | (0.008752)49 | — | ||
| ERLEC1 | rs2542571 | (0.00024)13,b | — | 0.33 | |
| TRIM46 | rs3814316 | (0.00052)13,b | — | 0.33 | |
| PRKRA | rs62176107 | (0.00086)13,b | — | 0.44 | |
| rs77419724 | (0.00014)13,b | 0.5 | |||
| BPIFB1 | rs1078761 | (0.00102)13,b | — | 0.28 | |
| CHST3 | Cell adhesion | rs4148913 | (6.82 × 10−5)8,b | — | 0.36 |
| NOS | rs1799983 | (0.02)84 | — | 0.99 | |
| rs2070744 | (0.04)84; (0.05)85 | — | 0.99 | ||
| SELL | rs2229569 | (0.04)86 | (>0.05)8 | 1 | |
| VNN2 | rs1883617 | (0.00101)84,b | — | 0.25 | |
| NUAK1 | rs1427793 | (1.09 × 10−6)49 | — | ||
| KITLG | Other | rs11104948 | (9 × 10−6)87 | — | 0.99 |
| rs4842477 | (0.015)87 | — | 0.97 | ||
| rs10858753 | (0.016)87 | — | 0.91 | ||
| rs11104906 | (0.017)87 | — | 0.97 | ||
| rs17424193 | (0.020)87 | — | 0.96 | ||
| rs869408 | (0.030)87 | — | 0.95 |
We consider SNPs for which at least one nominally significant association was reported. SIGN. LITERATURE and NOT SIGN. LITERATURE: literature results were stratified by the presence of significant associations with BPD or related phenotypes and the respective reported p value is shown. The reference is provided as superscript. The power to replicate significant findings is shown in the last column.
SIGN. significant, ref. reference.
aThe power estimate is missing if effect estimates or standard errors could not be retrieved from the publications. If multiple significant effect sizes are reported from different studies, the smallest power estimate is shown. See also Supplementary Table 1 for more details.
bGWAS study.