Table 2.
Characterization of the study cohort.
| Characteristics | Total (N = 1061) | Controls (N = 670)/(N = 670) | Cases (N = 278) | p Value |
|---|---|---|---|---|
| GA, mean weeks (min; max; s.d.) | 27 (22.3; 34.9;2.2) | 27.2 (22.3; 32; 2.2) | 26.3 (22.3; 32; 2) | 1.79 × 10−7 |
| BW, mean in g (min; max; s.d.) | 843 (270; 1700;270.9) | 884 (370; 1700; 265) | 748.8 (270; 1490; 252.5) | 1.15 × 10−10 |
| SGA, n (%) | 290 (27.3) | 165 (24.6) | 88 (31.7) | 0.0278 |
| Sex, n (%) female | 469 (44.2) | 303 (45.2) | 116 (41.7) | 0.325 |
| Mother country | ||||
| Germany, N (%) | 68 (6.4) | 578 (86.3) | 242 (87.1) | 0.75 |
| Other European, N (%) | 919 (86.6) | 44 (6.6) | 17 (6.1) | 0.8 |
| Turkey, N (%) | 746 (7) | 48 (7.2) | 19 (6.8) | 0.859 |
| Twins, N (%) | 297 (28) | 192 (28.7) | 76 (27.3) | 0.68 |
| Deaths, N (%) | 39 (3.7) | 3 (0.4) | 31 (11.2) | 4.65 × 10−8 |
| Suppl. oxygen, mean days (min; max; s.d.) | 53.1 (0; 323; 46.7) | 27.8 (0; 86; 25.3) | 93.5 (3; 323; 47.7) | <2 × 10−16 |
| Mechanical ventilation, mean days (min; max; s.d.) | 15.9 (0; 281; 25.0) | 9.1 (0; 85; 13.1) | 30.6 (0; 281; 38.1) | 8.74 × 10−14 |
| CPAP, mean days (min; max; s.d.) | 49.0 (0; 435; 37.4) | 41 (0; 435; 32) | 72.6 (1; 281; 42) | <2 × 10−16 |
Shown are phenotype characteristics including duration of respiratory support (namely supplemental oxygen Suppl. Ox.), mechanical ventilation and CPAP. Significance levels are calculated considering relatedness. Note that not all individuals with information on respiratory support could be classified in cases or controls.
GA gestational age, BW birth weight, SGA small gestational age, min minimum, max maximum, s.d.standard deviation