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. 2022 May 23;9:907485. doi: 10.3389/fsurg.2022.907485

Table 1.

Demographic and clinical data of patients in analysis.

Total Group1
Group2
Group3
197 Low (101) High (96) p value Low (83) High (114) p value Low (117) High (80) p value
Sex 0.578 0.104 0.299
Female 27 (13.7%) 12 (6.1%) 15 (7.6%) 7 (3.6%) 20 (10.2%) 19 (9.6%) 8 (4.1%)
 Male 170 (86.3%) 89 (45.2%) 81 (41.1%) 76 (38.6%) 94 (47.7%) 98 (49.7%) 72 (36.5%)
 Age 64.17±11.05 64.89±10.76 63.41±11.41 0.348 65.02±11.14 63.54±11.04 0.356 63.91±10.89 64.55±11.41 0.690
BMI 23.65±3.04 23.75±3.16 23.54±2.94 0.641 23.9±2.68 23.46±3.29 0.323 23.53±2.87 23.82±3.29 0.521
Smoker 0.820 0.637 0.836
 No 140 (71.1%) 73 (37.1%) 67 (34%) 57 (28.9%) 83 (42.1%) 82 (41.6%) 58 (29.4%)
 Yes 57 (28.9%) 28 (14.2%) 29 (14.7%) 26 (13.2%) 31 (15.7%) 35 (17.8%) 22 (11.2%)
Gross hematuria 1.000 0.455
 No 46 (23.4%) 24 (12.2%) 22 (11.2%) 20 (10.2%) 26 (13.2%) 30 (15.2%) 16 (8.1%)
 Yes 151 (76.6%) 77 (39.1%) 74 (37.6%) 63 (32%) 88 (44.7%) 87 (44.2%) 64 (32.5%)
Hypertension 0.035 0.164
 No 140 (71.1%) 79 (40.1%) 61 (31%) 63 (32%) 77 (39.1%) 88 (44.7%) 52 (26.4%)
 Yes 57 (28.9%) 22 (11.2%) 35 (17.8%) 20 (10.2%) 37 (18.8%) 29 (14.7%) 28 (14.2%)
Diabetes 0.770 0.654 0.248
 No 172 (87.3%) 87 (44.2%) 85 (43.1%) 74 (37.6%) 98 (49.7%) 99 (50.3%) 73 (37.1%)
 Yes 25 (12.7%) 14 (7.1%) 11 (5.6%) 9 (4.6%) 16 (8.1%) 18 (9.1%) 7 (3.6%)
Tumor size 0.586 0.263
 ≤3 cm 110 (55.8%) 54 (27.4%) 56 (28.4%) 50 (25.4%) 60 (30.5%) 61 (31%) 49 (24.9%)
 >3 cm 87 (44.2%) 47 (23.9%) 40 (20.3%) 33 (16.8%) 54 (27.4%) 56 (28.4%) 31 (15.7%)
Tumor number 0.456 0.215 0.027
 Single 86 (43.7%) 41 (20.8%) 45 (22.8%) 41 (20.8%) 45 (22.8%) 43 (21.8%) 43 (21.8%)
 Multiple 111 (56.3%) 60 (30.5%) 51 (25.9%) 42 (21.3%) 69 (35%) 74 (37.6%) 37 (18.8%)
WHO grade 0.590 0.957
 Low 55 (27.9%) 26 (13.2%) 29 (14.7%) 23 (11.7%) 32 (16.2%) 32 (16.2%) 23 (11.7%)
 High 142 (72.1%) 75 (38.1%) 67 (34%) 60 (30.5%) 82 (41.6%) 85 (43.1%) 57 (28.9%)
CIS 0.770 0.084 1.000
 No 182 (92.4%) 87 (44.2%) 85 (43.1%) 73 (37.1%) 109 (55.3%) 108 (54.8%) 74 (37.6%)
 Yes 15 (7.6%) 14 (7.1%) 11 (5.6%) 10 (5.1%) 5 (2.5%) 9 (4.6%) 6 (3%)
T stage 0.020 1.000 0.248
 Ta 40 (20.3%) 27 (13.7%) 12 (6.1%) 16 (8.1%) 23 (11.7%) 26 (13.2%) 13 (6.6%)
 T1 157 (79.7%) 74 (37.6%) 84 (42.6%) 67 (34%) 91 (46.2%) 91 (46.2%) 67 (34%)
Histology 0.441 0.535 0.207
 PTCC 171 (86.8%) 90 (45.7%) 81 (41.1%) 74 (37.6%) 97 (49.2%) 105 (53.3%) 66 (33.5%)
 HV 26 (13.2%) 11 (5.6%) 15 (7.6%) 9 (4.6%) 17 (8.6%) 12 (6.1%) 14 (7.1%)
Recurrence 0.009 1.000
 No 112 (56.9%) 67 (34%) 45 (22.8%) 57 (28.9%) 55 (27.9%) 67 (34%) 45 (22.8%)
 Yes 85 (43.1%) 34 (17.3%) 51 (25.9%) 26 (13.2%) 59 (29.9%) 50 (25.4%) 35 (17.8%)
Progression 0.070 0.957
 No 142 (72.1%) 79 (40.1%) 63 (32%) 69 (35%) 73 (37.1%) 85 (43.1%) 57 (28.9%)
 Yes 55 (27.9%) 22 (11.2%) 33 (16.8%) 14 (7.1%) 41 (20.8%) 32 (16.2%) 23 (11.7%)
Risk group 0.375 0.861 0.396
 Intermediate 62 (31.4%) 34 (33.7%) 28 (29.2%) 26 (31.3%) 36 (31.6%) 38 (32.5%) 24 (30%)
 High 114 (57.9%) 54 (53.5%) 60 (62.5%) 47 (56.6%) 67 (58.8%) 64 (54.7%) 50 (62.5%)
 Very high 21 (21.6%) 13 (12.9%) 8 (8.3%) 10 (12.0%) 11 (9.6%) 15 (12.8%) 6 (7.5%)

CIS, carcinoma in situ.