Skip to main content
. 2022 Aug 12;13:863034. doi: 10.3389/fimmu.2022.863034

Figure 6.

Figure 6

OXA-induced colitis could be ameliorated by blocking IL-13/STAT6 signaling pathway in DEX injected mice. RCM-1 (1.7 mg/kg) was injected to mice with DEX to block STAT6 signaling and then 1% OXA was given to induce colitis. (A) Body weight changes of control, DEX injection, DEX + RCM-1 injection mice after OXA enema. (B, C) Colon length at day 1 after 1% OXA enema of control, DEX injection, DEX + RCM-1 injection mice. (D, E) Representative HE staining [×20] and pathological score of inflamed colon tissue of control, DEX injection, DEX+RCM-1 injection mice. (F, G) qPCR of Il-6 and Tnf-α mRNA in colonic tissues in control, DEX injection, DEX + RCM-1 injection mice at day 1 after 1% OXA enema. (H) Immunoblot for ZO-1 and Occludin in colonic tissue in control, DEX injection and DEX + RCM-1 injection mice at day 1 after 1% OXA enema. Data are representative of at least two independent experiments. Data are shown as mean ± SEM. *p <0.05; **p <0.01; ***p <0.001; ****p <0.0001.